Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Spatial Allocation and Specification of Cardiomyocytes during Zebrafish Embryogenesis

  • Fukui, Hajime (Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute) ;
  • Chiba, Ayano (Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute) ;
  • Miyazaki, Takahiro (Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute) ;
  • Takano, Haruko (Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute) ;
  • Ishikawa, Hiroyuki (Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute) ;
  • Omori, Toyonori (Management office, National Center for Child Health and Development) ;
  • Mochiuzki, Naoki (Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute)
  • Received : 2016.07.26
  • Accepted : 2016.10.13
  • Published : 2017.03.31
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Abstract

Incomplete development and severe malformation of the heart result in miscarriage of embryos because of its malfunction as a pump for circulation. During cardiogenesis, development of the heart is precisely coordinated by the genetically-primed program that is revealed by the sequential expression of transcription factors. It is important to investigate how spatial allocation of the heart containing cardiomyocytes and other mesoderm-derived cells is determined. In addition, the molecular mechanism underlying cardiomyocyte differentiation still remains elusive. The location of ectoderm-, mesoderm-, and endoderm-derived organs is determined by their initial allocation and subsequent mutual cell-cell interactions or paracrine-based regulation. In the present work, we provide an overview of cardiac development controlled by the germ layers and discuss the points that should be uncovered in future for understanding cardiogenesis.

Keywords

References

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