Psychiatry investigation

Korean Neuropsychiatric Association (대한신경정신의학회)
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Association of Serotonin 1A Receptor Polymorphism with Variation in Health-Related Quality of Life in Korean Hemodialysis Patients

  • Park, Hyeong Cheon (Department of Internal Medicine, Gangnam Severance Hospital, Institute for Vascular and Metabolic Research, Yonsei University College of Medicine) ;
  • Park, Sunyoung (Department of Psychiatry, Gangnam Severance Hospital, Institute for Behavioral Science in Medicine, Yonsei University College of Medicine) ;
  • Choi, Hoon Young (Department of Internal Medicine, Gangnam Severance Hospital, Institute for Vascular and Metabolic Research, Yonsei University College of Medicine) ;
  • Lee, Jung Eun (Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine) ;
  • Park, Hae Yeul (Department of Internal Medicine, Gangnam Severance Hospital, Institute for Vascular and Metabolic Research, Yonsei University College of Medicine) ;
  • Kim, Seok-hyung (Department of Internal Medicine, Gangnam Severance Hospital, Institute for Vascular and Metabolic Research, Yonsei University College of Medicine) ;
  • Ha, Sung Kyu (Department of Internal Medicine, Gangnam Severance Hospital, Institute for Vascular and Metabolic Research, Yonsei University College of Medicine) ;
  • Seok, Jeong-Ho (Department of Psychiatry, Gangnam Severance Hospital, Institute for Behavioral Science in Medicine, Yonsei University College of Medicine)
  • Received : 2016.03.28
  • Accepted : 2016.06.22
  • Published : 2017.07.25
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Abstract

Objective Hemodialysis patients may have psychological distress and reduced quality of life (QoL) related to chronic physical health problems. Genetic polymorphisms associated with reduced QoL in hemodialysis patients. The aim of this study was to investigate the relationship between genetic polymorphisms and variation in health-related QoL in Korean hemodialysis patients. Methods The 36-item Short-Form Health Survey and the Korean Hospital Anxiety and Depression Scale were used to assess health-related QoL and psychological distress, respectively. Twenty hundred and five clinically stable patients from 6 hemodialysis centers have participated with informed consents. Sociodemographic factors, clinical factors, and genotypes of serotonin 1A receptor, brain-derived neurotrophic factors, and glucocorticoid receptor were assessed. Independent t-tests, correlation analyses, multiple regression analyses were performed for statistical analyses. Results The serotonin 1A receptor CC genotype group showed significantly higher physical and mental QoL levels than those with the GG/GC genotypes. In the final linear regression analysis, serotonin 1A receptor CC genotype was significantly associated with positive physical and mental QoL levels. Conclusion Serotonin 1A receptor polymorphism, as well as age and depression, were significantly associated with mental and physical QoL in hemodialysis patients. Functional activity in the serotonin receptor system may have a modulating effect on health-related QoL in hemodialysis patients.

Keywords

Acknowledgement

Supported by : Ministry of Health & Welfare

References

  1. Kimmel PL, Peterson RA. Depression in end-stage renal disease patients treated with hemodialysis: tools, correlates, outcomes, and needs. Semin Dial 2005;18:91-97.
  2. Kimmel PL, Cukor D, Cohen SD, Peterson RA. Depression in end-stage renal disease patients: a critical review. Adv Chronic Kidney Dis 2007;14:328-334. https://doi.org/10.1053/j.ackd.2007.07.007
  3. Manns B, Johnson J, Taub K, Mortis G, Ghali W, Donaldson C. Quality of life in patients treated with hemodialysis or peritoneal dialysis: what are the important determinants? Clin Nephrol 2003;60:341-351. https://doi.org/10.5414/CNP60341
  4. Howren MB, Lamkin DM, Suls J. Associations of depression with Creactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med 2009; 71:171-186. https://doi.org/10.1097/PSY.0b013e3181907c1b
  5. Neumeister A, Young T, Stastny J. Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter. Psychopharmacology (Berl) 2004;174:512-524.
  6. Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, et al. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 2003;23:8788-8799. https://doi.org/10.1523/JNEUROSCI.23-25-08788.2003
  7. Strobel A, Gutknecht L, Rothe C, Reif A, Mossner R, Zeng Y, et al. Allelic variation in 5-HT1A receptor expression is associated with anxiety-and depression-related personality traits. J Neural Transm (Vienna) 2003;110:1445-1453. https://doi.org/10.1007/s00702-003-0072-0
  8. Verhagen M, van der Meij A, van Deurzen P, Janzing JG, Arias-Vasquez A, Buitelaar J, et al. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol Psychiatry 2008;15:260-271.
  9. Choi MJ, Kang RH, Lim SW, Oh KS, Lee MS. Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder. Brain Res 2006;1118:176-182. https://doi.org/10.1016/j.brainres.2006.08.012
  10. Kang R, Chang H, Wong M, Choi M, Park J, Lee H, et al. Brain-derived neurotrophic factor gene polymorphisms and mirtazapine responses in Koreans with major depression. J Psychopharmacol 2010;24:1755-1763. https://doi.org/10.1177/0269881109105457
  11. Kang JI, Chung HC, Jeung HC, Kim SJ, An SK, Namkoong K. FKBP5 polymorphisms as vulnerability to anxiety and depression in patients with advanced gastric cancer: a controlled and prospective study. Psychoneuroendocrinology 2012;37:1569-1576. https://doi.org/10.1016/j.psyneuen.2012.02.017
  12. Lekman M, Laje G, Charney D, Rush AJ, Wilson AF, Sorant AJ, et al. The FKBP5 Gene in Depression and Treatment Response-an Association Study in the Sequenced Treatment Alternatives to Relieve Depression (STAR* D) Cohort. Biol Psychiatry 2008;63:1103-1110. https://doi.org/10.1016/j.biopsych.2007.10.026
  13. Wang LJ, Chen CK, Hsu HJ, Wu IW, Sun CY, Lee CC. Depression, 5HTTLPR and BDNF Val66Met polymorphisms, and plasma BDNF levels in hemodialysis patients with chronic renal failure. Neuropsychiatr Dis Treat 2014;10:1235-1241.
  14. Ulusoy S, Gungor E, Gul S, Ozkan G, Karahan SC, Sit D, et al. Do hemodialysis adequacy data reflect reality? Artif Organs 2013;37:189-195. https://doi.org/10.1111/j.1525-1594.2012.01537.x
  15. Jenkinson C, Coulter A, Wright L. Short form 36 (SF36) health survey questionnaire: normative data for adults of working age. BMJ 1993; 306:1437-1440. https://doi.org/10.1136/bmj.306.6890.1437
  16. Ware JE Jr, Gandek B. Overview of the SF-36 Health Survey and the International Quality of Life Assessment (IQOLA) Project. J Clin Epidemiol 1998;51:903-912. https://doi.org/10.1016/S0895-4356(98)00081-X
  17. Han CW, Lee EJ, Iwaya T, Kataoka H, Kohzuki M. Development of the Korean Version of Short-Form 36-Item Health Survey: Health Related QOL of Healthy Elderly People and Elderly Patients in Korea. Tohoku J Exp Med 2004;203:189-194. https://doi.org/10.1620/tjem.203.189
  18. Nam BH, Lee SW. Testing the validity of the Korean SF-36 health survey. J Korean Soc Health Stat 2003;28:3-24.
  19. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983;67:361-370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x
  20. Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res 2002;52:69-77. https://doi.org/10.1016/S0022-3999(01)00296-3
  21. Oh SM, Min KJ, Park DB. A study on the standardization of the hospital anxiety and depression scale for Koreans: a comparison of normal, depressed and anxious groups. J Korean Neuropsychiatr Assoc 1999; 38:289-296.
  22. Zou YF, Wang Y, Liu P, Feng XL, Wang BY, Zang TH, et al. Association of BDNF Val66Met polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine. Hum Psychopharmacol Clin 2010;25:145-152. https://doi.org/10.1002/hup.1099
  23. Parsey RV, Oquendo MA, Ogden RT, Olvet DM, Simpson N, Huang YY, et al. Altered serotonin 1A binding in major depression: a [carbonyl-C-11] WAY100635 positron emission tomography study. Biol Psychiatry 2006;59:106-113. https://doi.org/10.1016/j.biopsych.2005.06.016
  24. Richardson-Jones JW, Craige CP, Guiard BP, Stephen A, Metzger KL, Kung HF, et al. 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron 2010;65:40-52. https://doi.org/10.1016/j.neuron.2009.12.003
  25. Rothe C, Gutknecht L, Freitag C, Tauber R, Mossner R, Franke P, et al. Association of a functional-1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia. Int J Neuropsychopharmacol 2004;7:189-192. https://doi.org/10.1017/S1461145703004061
  26. Hong C, Chen T, Yu YW, Tsai S. Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. Pharmacogenomics J 2005;6:27-33. https://doi.org/10.1517/14622416.6.1.27
  27. Yu YW, Tsai SJ, Liou YJ, Hong CJ, Chen TJ. Association study of two serotonin 1A receptor gene polymorphisms and fluoxetine treatment response in Chinese major depressive disorders. Eur Neuropsychopharmacol 2006;16:498-503. https://doi.org/10.1016/j.euroneuro.2005.12.004
  28. Mekli K, Payton A, Miyajima F, Platt H, Thomas E, Downey D, et al. The HTR1A and HTR1B receptor genes influence stress-related information processing. Eur Neuropsychopharmacol 2011;21:129-139. https://doi.org/10.1016/j.euroneuro.2010.06.013
  29. Lindstedt F, Lonsdorf TB, Schalling M, Kosek E, Ingvar M. Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene. PLoS One 2011;6:e17752. https://doi.org/10.1371/journal.pone.0017752
  30. Lindstedt F, Karshikoff B, Schalling M, Olgart Hoglund C, Ingvar M, Lekander M, et al. Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception. PLoS One 2012;7:e43221. https://doi.org/10.1371/journal.pone.0043221
  31. Amin N, Hottenga JJ, Hansell NK, Janssens AC, de Moor MH, Madden PA, et al. Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions. Eur J Hum Genet 2013;21:876-882. https://doi.org/10.1038/ejhg.2012.263
  32. Kim HN, Roh SJ, Sung YA, Chung HW, Lee JY, Cho J, et al. Genome-wide association study of the five-factor model of personality in young Korean women. J Hum Genet 2013;10:667-674.
  33. Sloan JA, Zhao CX. Genetics and quality of life. Curr Probl Cancer 2006;30:255-260. https://doi.org/10.1016/j.currproblcancer.2006.09.001
  34. Ortega-Hernandez OD, Cuccia M, Bozzini S, Bassi N, Moscavitch S, Diaz-Gallo LM, et al. Autoantibodies, Polymorphisms in the Serotonin Pathway, and Human Leukocyte Antigen Class II Alleles in Chronic Fatigue Syndrome. Ann N Y Acad Sci 2009;1173:589-599. https://doi.org/10.1111/j.1749-6632.2009.04802.x
  35. Sprangers MA, Thong MS, Bartels M, Barsevick A, Ordonana J, Shi Q, et al. Biological pathways, candidate genes, and molecular markers associated with quality-of-life domains: an update. Qual Life Res 2014; 23:1997-2013. https://doi.org/10.1007/s11136-014-0656-1
  36. Rebollo P, Ortega F, Baltar JM, Diaz-Corte C, Navascues RA, Naves M, et al. Health-related quality of life (HRQOL) in end stage renal disease (ESRD) patients over 65 years. Geriatr Nephrol Urol 1998;8:85-94. https://doi.org/10.1023/A:1008338802209
  37. Neves P. Chronic haemodialysis in elderly patients. Neprhol Dial Transpl 1995;10(Suppl 6):69-71.
  38. Morgan B. The relationship between chronological age and perceived quality of life of hemodialysis patients. ANNA J 1990;17:63-66, discussion 67.
  39. Amato M, Ponziani G, Rossi F, Liedl C, Stefanile C, Rossi L. Quality of life in multiple sclerosis: the impact of depression, fatigue and disability. Mult Scler 2001;7:340-344. https://doi.org/10.1177/135245850100700511
  40. Wells KB, Stewart A, Hays RD, Burnam MA, Rogers W, Daniels M, et al. The functioning and well-being of depressed patients: results from the Medical Outcomes Study. JAMA 1989;262:914-919. https://doi.org/10.1001/jama.1989.03430070062031
  41. Castelli WP, Doyle JT, Gordon T, Hames CG, Hjortland MC, Hulley SB, et al. HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study. Circulation 1977;55:767-772. https://doi.org/10.1161/01.CIR.55.5.767
  42. Jahangiry L, Shojaeezadeh D, Montazeri A, Najafi M, Mohammad K. Health-related quality of life among people participating in a metabolic syndrome e-screening program: a web-based study. Int J Prev Med 2016;7:27. https://doi.org/10.4103/2008-7802.174893
  43. Kimmel PL, Emont SL, Newmann JM, Danko H, Moss AH. ESRD patient quality of life: symptoms, spiritual beliefs, psychosocial factors, and ethnicity. Am J Kidney Dis 2003;42:713-721. https://doi.org/10.1016/S0272-6386(03)00907-7
  44. Merkus MP, Jager KJ, Dekker FW, Boeschoten EW, Stevens P, Krediet RT. Quality of life in patients on chronic dialysis: self-assessment 3 months after the start of treatment. The Necosad Study Group. Am J Kidney Dis 1997;29:584-592. https://doi.org/10.1016/S0272-6386(97)90342-5

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