Psychiatry investigation

Korean Neuropsychiatric Association (대한신경정신의학회)
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Balance Deficit and Brain Connectivity in Children with Attention-Deficit/Hyperactivity Disorder

  • Kim, Sun Mi (Department of Psychiatry, Chung-Ang University Hospital) ;
  • Hyun, Gi Jung (Department of Psychiatry, Chung-Ang University Hospital) ;
  • Jung, Tae-Woon (Department of Therapeutic Riding, Jeonju Kijeon College) ;
  • Son, Young Don (Department of Biomedical Engineering, Gachon University Gil Medical Center) ;
  • Cho, In-Hee (Dr. Cho's Child & Adolescent Psychiatric Clinic) ;
  • Kee, Baik Seok (Department of Psychiatry, Chung-Ang University Hospital) ;
  • Han, Doug Hyun (Department of Psychiatry, Chung-Ang University Hospital)
  • Received : 2016.02.04
  • Accepted : 2016.06.30
  • Published : 2017.07.25
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Abstract

Objective We aimed to assess disturbances in postural and gait balance and functional connectivity within the brain regions controlling balance in children with attention-deficit/hyperactivity disorder (ADHD). Methods Thirteen children with ADHD and 13 age- and sex-matched controls were recruited. Gait balance was assessed by the difference in the center of pressure (COP) between the left and right foot, as well as the difference in plantar pressure between the left and right foot during gait. Neuroimaging data were acquired using a 3.0 Tesla MRI scanner. Functional connectivity between the vermis of the cerebellum and all other brain regionswas assessed. Results The difference in plantar pressure between the left foot and right foot in the ADHD group was greater than that observed in the control group. The average COP jerk score of the right foot in the ADHD group was higher than that observed in the control group. A higher functional connectivity between the cerebellum and the right middle frontal gyrus (premotor cortex) and medial frontal gyrus (cingulate gyrus) was observed in the control group relative to the ADHD group. In the ADHD group, the difference in plantar pressure between the left and right foot was also negatively correlated with the beta-value within the middle frontal gyrus. Conclusion Children with ADHD had disturbance of balance as assessed by plantar pressure. Decreased brain connectivity from the cerebellum to the premotor cortex and anterior cingulate was associated with disturbances of posture and balance in children with ADHD.

Keywords

Acknowledgement

Supported by : Ministry of Health & Welfare, Korea Creative Content Agency

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