Psychiatry investigation

Korean Neuropsychiatric Association (대한신경정신의학회)
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Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

  • Cho, Chul-Hyun (Department of Psychiatry, Korea University College of Medicine) ;
  • Ahn, Yong-Min (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Kim, Se Joo (Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine) ;
  • Ha, Tae Hyun (Department of Psychiatry, Seoul National University Bundang Hospital, College of Medicine) ;
  • Jeon, Hong Jin (Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Cha, Boseok (Department of Psychiatry, Gyeongsang National University College of Medicine) ;
  • Moon, Eunsoo (Department of Psychiatry, Pusan National University School of Medicine) ;
  • Park, Dong Yeon (Department of Psychiatry, Seoul National Hospital) ;
  • Baek, Ji Hyun (Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kang, Hee-Ju (Department of Psychiatry, Chonnam National University College of Medicine) ;
  • Ryu, Vin (Department of Psychiatry, Seoul National Hospital) ;
  • An, Hyonggin (Department of Biostatistics, Korea University College of Medicine) ;
  • Lee, Heon-Jeong (Department of Psychiatry, Korea University College of Medicine)
  • Received : 2016.06.18
  • Accepted : 2016.08.04
  • Published : 2017.01.25
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Abstract

The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2) in South Korea. The study subjects consist of two populations: 1) patients with mood disorders under 25 years old and 2) patients with mood disorders within 2 years of treatment under 35 years old. After successful screening, the subjects are evaluated using baseline assessments and serial follow-up assessments at 3-month intervals. Between the follow-up assessments, subjects are dictated to check their own daily mood status before bedtime using the eMood chart application or a paper mood diary. At the regular visits every 3 months, inter-visit assessments are evaluated based on daily mood charts and interviews with patients. In addition to the daily mood chart, sleep quality, inter-visit major and minor mood episodes, stressful life events, and medical usage pattern with medical expenses are also assessed. Genomic DNA from blood is obtained for genomic analyses. From the MDCRC study, the clinical course, prognosis, and related factors of early-onset mood disorders can be clarified. The MDCRC is also able to facilitate translational research for mood disorders and provide a resource for the convergence study of mood disorders.

Keywords

Acknowledgement

Supported by : Ministry of Health & Welfare

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