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Diffuse Large B-Cell Lymphoma in the Era of Precision Oncology: How Imaging Is Helpful

  • Shah, Hina J. (Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School) ;
  • Keraliya, Abhishek R. (Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School) ;
  • Jagannathan, Jyothi P. (Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School) ;
  • Tirumani, Sree Harsha (Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School) ;
  • Lele, Vikram R. (Department of Nuclear Medicine and PET/CT, Jaslok Hospital and Research Centre) ;
  • DiPiro, Pamela J. (Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School)
  • Received : 2016.08.25
  • Accepted : 2016.08.29
  • Published : 2017.01.01

Abstract

Diffuse large B cell lymphoma (DLBCL) is the most common histological subtype of Non-Hodgkin's lymphoma. As treatments continues to evolve, so do imaging strategies, and positron emission tomography (PET) has emerged as the most important imaging tool to guide oncologists in the diagnosis, staging, response assessment, relapse/recurrence detection,and therapeutic decision making of DLBCL. Other imaging modalities including magnetic resonance imaging (MRI), computed tomography (CT), ultrasound, and conventional radiography are also used in the evaluation of lymphoma. MRI is useful for nervous system and musculoskeletal system involvement and is emerging as a radiation free alternative to PET/CT. This article provides a comprehensive review of both the functional and morphological imaging modalities, available in the management of DLBCL.

Keywords

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