Natural Product Sciences

  • 제23권3호
  • /
  • Pages.208-212
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  • 2017
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
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Sesquiterpenoids from the heartwood of Juniperu s chinensis

  • Jung, Hee Jin (Department of Food and Life Science, Pukyong National University) ;
  • Min, Byung-Sun (College of Pharmacy, Catholic University of Daegu) ;
  • Jung, Hyun Ah (Department of Food Science and Human Nutrition, Chonbuk National University) ;
  • Choi, Jae Sue (Department of Food and Life Science, Pukyong National University)
  • 투고 : 2017.04.05
  • 심사 : 2017.06.10
  • 발행 : 2017.09.29
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초록

A new sesquiterpenoid, 11-hydroxy-valenc-1(10),3(4)-dien-2-one (3), two chemically synthesized but first isolate from nature, $3-oxocedran-8{\beta}-ol$ (1) and valenc-1(10),3(4),11(12)-trien-2-one (2) along with four known compounds, sugiol (4), (+)-nootkatone (5), 11-hydroxy-valenc-1(10)-en-2-one (6), and clovandiol (7), were isolated from the heartwood of Juniperus chinensis. All chemical structures were elucidated using extensive spectroscopic analysis including 1D and 2D NMR spectroscopy. Valenc-1(10),3(4),11(12)-trien-2-one (2) exhibited significant inhibitory activity against butyrylcholinesterase with an $IC_{50}$ value of $68.45{\mu}M$.

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참고문헌

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피인용 문헌

  1. The Current Status of the Pharmaceutical Potential of Juniperus L. Metabolites vol.5, pp.3, 2017, https://doi.org/10.3390/medicines5030081
  2. Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy vol.11, pp.3, 2017, https://doi.org/10.3390/biom11030350
  3. Eudesmane and Eremophilane Sesquiterpenes from the Fruits of Alpinia oxyphylla with Protective Effects against Oxidative Stress in Adipose-Derived Mesenchymal Stem Cells vol.26, pp.6, 2017, https://doi.org/10.3390/molecules26061762