대한본초학회지 (The Korea Journal of Herbology)

  • 제32권5호
  • /
  • Pages.1-6
  • /
  • 2017
  • /
  • 1229-1765(pISSN)
  • /
  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지
DOI QR코드

DOI QR Code

산수유의 최종당화산물 억제로 인한 주름 개선효과

Corni Fructus Inhibits Wrinkle Formation by Reduced Advanced glycation end product (AGEs)

  • 이아름 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김수현 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김수지 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김경조 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 권오준 (경북지역사업평가단) ;
  • 최준영 (농업회사법인 새얼 바이오푸드 주식회사) ;
  • 노성수 (대구한의대학교 한의과대학 본초약리학교실)
  • Lee, AhReum (College of Korean Medicine, Daegu Haany University) ;
  • Kim, SooHyun (College of Korean Medicine, Daegu Haany University) ;
  • Kim, SuJi (College of Korean Medicine, Daegu Haany University) ;
  • Kim, KyeongJo (College of Korean Medicine, Daegu Haany University) ;
  • Kwon, Ojun (Gyeongbuk Institute for Regional Program Evaluation) ;
  • Choi, JoonYoung (Sae Earl Bio Food co., Ltd) ;
  • Roh, Seong-Soo (College of Korean Medicine, Daegu Haany University)
  • 투고 : 2017.07.26
  • 심사 : 2017.09.15
  • 발행 : 2017.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives : Corni Fructus (CF) is traditional herbal medicine used on polyuria, low back pain, and tinnitus. This study aimed to evaluate inhibits skin wrinkle formation effect of CF. Methods : To evaluate the produce inhibition effect of CF, SD-rats were distributed into four groups; normal rats (Nor), AGEs (advenced glycation end product)-induced rats (Con), AGEs-induced rats treated with 100mg/kg CF (CF). To induce AGEs, streptozotocin (50mg/kg) was administered intraperitoneally and after 3 days oral administrated 100mM methyl glyoxal for 3 weeks. Results : The oral administration of CF suppressed the reactive oxygen specis (ROS) in serum. The AGEs in skin tissues was significantly reduced through treatment of CF. Furthermore, the expressions of AGEs related proteins such as polyclonal anti-$N^e$-(carboxymethyl)lysine (CML), anti-$N^e$-(carboxyethyl)lysine (CEL), AGE receptors (RAGE) were decreased in CF treated group compared with the control group in skin tissues. Inflammation-related proteins such as Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) reduced in CF treatment group than control group. AGE-induced rats exhibited that the significant decreased collagen however, CF treatment (100mg/kg of body weight) up regulated collagen by improved the expression levels of skin fibril-related genes such as Matrix metalloproteinase (MMP-1). Conclusion : Taken together, our study suggests that CF regulates ROS to prevent accumulation of AGEs and inhibits skin wrinkles. Our finding indicate that CF may be an effective agent for inhibits AGEs formation, and improved skin wrinkle.

키워드

참고문헌

  1. Kwon SH, Yang HS, Kim JY, Park KW, Shon MY, Kang KS, Shim KH, Seo KI. Biological activities of ethanol extract from Corni Fructus. J Korean Soc Food Sci Nutr. 2009 ; 38(3) : 287-91. https://doi.org/10.3746/jkfn.2009.38.3.287
  2. Lee MH, Kim JM, Park EJ. Antioxidant and antigenotoxic effects of Sansuyu Fruit (Corni Fructus) extracted with water at different temperatures. J Korean Soc Food Sci Nutr. 2011 ; 40(2) : 149-55. https://doi.org/10.3746/jkfn.2011.40.2.149
  3. Han YK, Park YK. The comparisons of Lycii Radicis Cortex and Corn Fructus water extract effects on streptozotocin-induced diabetes in rats. Kor. J. Herbology. 2013 ; 28(6) : 71-77. https://doi.org/10.6116/KJH.2013.28.6.71
  4. Kim OK, Antidiabetic and antioxidative effects of Corni Fructus in streptozotocin-induced diabetic rats. J of Korean Oil Chemists Soc. 2005 ; 22(2) : 157-67.
  5. Jeon YH, Kim MH, Kim MR. Antioxidative, Antimutagenic, and Cytotoxic activities of ethanol extracts from Cornus officianalis. J Korean Soc Food Sci Nutr. 2008 ; 37(1) : 1-7. https://doi.org/10.3746/jkfn.2008.37.1.1
  6. Lee HJ, Lim HJ, Kim DH, Sim BY, Lim MH. Antiinflammatory effect of Cornus officinalis fruit extract for potential of cosmetic ingredient. Kor. J. Aesthet. Cosmetol. 2015 ; 13(4) : 461-68.
  7. Gkogkolou P, Bohm M. Advanced glycation end products: Key players in skin aging?. Dermatoendocrinology. 2012 ; 4(3) : 259-70. https://doi.org/10.4161/derm.22028
  8. Lee HS, Yoon JA. Inhibitory activity of advanced glycation end products (AGE) formation of edible plants for development of anti-wrinkle ingredients. J Korean Soc Food Sci Nutr. 2010 ; 39(2) : 186-92. https://doi.org/10.3746/jkfn.2010.39.2.186
  9. Singh R, Barden A, Mori T, Beilin L. Advanced glycation end products: a review. Diabetologia. 2001 ; 44(2) : 129-46. https://doi.org/10.1007/s001250051591
  10. Kim SH, Lee AR, Kim SJ, Kim KJ, Kwon OJ, Choi JY, Koo JS, Roh SS. Skin elasticity improvement effect of young persimmon and heated young persimmon by decreased advanced glycation end products (AGEs). Kor. J. Herbology. 2017 ; 32(4) : 17-24.
  11. Huebschmann AG, Regensteiner JG, Vlassara H, Reusch JEB. Diabetes and advanced glycoxidation end products. Diabetes Care 2006 ; 29(6) : 1420-32. https://doi.org/10.2337/dc05-2096
  12. Draelos ZD, Yatskayer M, Raab S, Oresajo C. An evaluation of the effect of a topical product containing C-xyloside and blueberry extract on the appearance of type II diabetic skin. J Cosmet Dermatol. 2009 ; 8(2) : 147-51. https://doi.org/10.1111/j.1473-2165.2009.00428.x
  13. Lee AR, Kwon OJ, Choi JY, Roh SS. Inhibitory Activity of Advanced Glycation Endproducts (AGEs) Formation and Antioxidant Activity of Processed Korean Medicines. Kor. J. Herbol. 2017 ; 32(3) : 63-9 https://doi.org/10.6116/kjh.2017.32.1.63.
  14. Lee SJ, Kim WG. Global trand in the beauty food market. Food Sci and Industry. 2005 ; 38(2) : 2-7.
  15. Kwon HO, Lee MH, Kim YJ, Kim E, Kim OK. Beneficial effects of Acanthopanax seticosus extract in type II diabetes animal model via downregulation of advanced glycated hemoglobin and glycosylation end products. J. Korean Soc Food Sci Nutr. 2016 ; 45(7) : 929-37. https://doi.org/10.3746/jkfn.2016.45.7.929
  16. Kim KJ, Kim KJ. Anti-skin-aging effects of Paeonia Suffruticosa ANdrews on maintaining skin collagen in STZ-induced diabetic rats and inhibiting MMP-1 systhesis in human skin fibroblasts. J. Korean oriental medical ophthalmology. 2008 ; 21(1) : 1-15.
  17. Kim SJ, Lee AR, Kim SH, Kim KJ, Kwon OJ, Choi JY, Koo JS, Roh SS. Skin wrinkle improvement effect of Paeoniae radix and processed Paeoniae radix through inhibition of advanced glycation end products (AGEs). Kor. J. Herbol. 2017 ; 32(4) : 53-60. https://doi.org/10.6116/KJH.2017.32.4.53
  18. Sung GA, Kim MH, Park SN. Anti-inflammatory and Whitening Effects of Protaetia brevitarsi Seulensis Extracts by Oriental Conversion Methods. J. Nutr Health. 2016 ; 49(4) : 233-40. https://doi.org/10.4163/jnh.2016.49.4.233
  19. Liotta LA, Steler-Stevenson WG. Metalloproteinases and cancer invasion. Seminars in Cancer Biology, 1990 ; 1(2) : 99-106.
  20. Bonfil RD, Reddel RR, Ura H, Reich R, Fridman R, Harris CC, Klein-Szanto JP. Invasive and metastatic potential of a v-Ha-ras-transformed human bronchial epithelial cell line. Journal of the National Cancer Institute, 1989 ; 81(8) : 587-94. https://doi.org/10.1093/jnci/81.8.587