Journal of the Korean neurological association (대한신경과학회지)

Korean Neurological Association (대한신경과학회)
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Co-occurrence of Guillain-Barré Syndrome and Acute Disseminated Encephalomyelitis with Dual Positive of Anti-GT1a and Anti-GM1 Antibodies

항GT1a 및 항GM1강글리오시드항체 동시 양성을 보인 길랭-바레증후군과 급성파종뇌척수염의 병발

  • Lee, Juyoung (Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Yoo, Jinhyuk (Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kang, Dong-gook (Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Yerim (Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Yoon, Byeol A (Department of Neurology, Dong-A University Hospital, Dong-A University College of Medicine) ;
  • Kim, Jong Kuk (Department of Neurology, Dong-A University Hospital, Dong-A University College of Medicine) ;
  • Bae, Jong Seok (Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine)
  • 이주영 (한림대학교 의과대학 강동성심병원 신경과) ;
  • 유진혁 (한림대학교 의과대학 강동성심병원 신경과) ;
  • 강동국 (한림대학교 의과대학 강동성심병원 신경과) ;
  • 김예림 (한림대학교 의과대학 강동성심병원 신경과) ;
  • 윤별아 (동아대학교 의과대학 동아대학교병원 신경과) ;
  • 김종국 (동아대학교 의과대학 동아대학교병원 신경과) ;
  • 배종석 (한림대학교 의과대학 강동성심병원 신경과)
  • Received : 2017.04.13
  • Accepted : 2017.06.26
  • Published : 2017.11.03
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Abstract

Acute disseminated encephalomyelitis (ADEM) and Guillain-$Barr{\acute{e}}$ syndrome (GBS) are both rare post-infectious neurological disorders. The co-existence of these conditions has often been reported despite of low incidence. We describe a 20-year-old male, who presented with acute flaccid paralysis and encephalopathy. The patient showed reversible MRI lesions suggesting ADEM. This case showed anti-GT1a IgG and anti-GM1 IgM antibodies positivity. We suggest that certain immunogenicity within central and peripheral nervous system may share a common autoimmune process during the disease course.

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Acknowledgement

Supported by : 한국과학재단