The Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지)

Korean Academy of Oral and Maxillofacial Pathology (대한구강악안면병리학회)
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Changes in Protein Expression of Oral Cancer Cells Continuosly Exposed to Porphyromonas gingivalis

Porphyromonas gingivalis에 지속적으로 노출된 구강암 세포의 단백발현 변화

  • Wi, Sin Wook (Department of Oral Pathology, School of Dentistry, Pusan National University) ;
  • Woo, Bok Hee (Department of Oral Pathology, School of Dentistry, Pusan National University) ;
  • Kim, Da Jeong (Department of Oral Pathology, School of Dentistry, Pusan National University) ;
  • Lee, Ji Hye (Department of Oral Pathology, School of Dentistry, Pusan National University) ;
  • Park, Bong Soo (BK21 PLUS Project, School of Dentistry, Pusan National University) ;
  • Park, Hae Ryoun (Department of Oral Pathology, School of Dentistry, Pusan National University)
  • 위신욱 (부산대학교 치의학전문대학원 구강병리학교실) ;
  • 우복희 (부산대학교 치의학전문대학원 구강병리학교실) ;
  • 김다정 (부산대학교 치의학전문대학원 구강병리학교실) ;
  • 이지혜 (부산대학교 치의학전문대학원 구강병리학교실) ;
  • 박봉수 (부산대학교 치의학전문대학원 BK21플러스 사업단) ;
  • 박혜련 (부산대학교 치의학전문대학원 구강병리학교실)
  • Received : 2017.01.04
  • Accepted : 2017.01.31
  • Published : 2017.02.28
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Abstract

Porphyromonas gingivalis is a gram-negative bacteria of rod shape, and grown in an anerobic condition. It colonizes in subgingival crevice and is known as a major pathogen causing chronic periodontitis. It possesses an invasive property and replicative potential within various cell types, presumably playing an important role in modulating biological behaviors of oral cancer. However, the pathophysiology of P. gingivalis in the malignant transformation of oral cancer has not been fully understood. In this study, we aimed to investigate molecular changes of oral squamous cell carcinoma cells induced by repetitive P. gingivalis infection that clinically resembles chronic periodontitis.

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Acknowledgement

Supported by : 부산대학교