Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Monitoring and Risk Assessment of Benzo(a)pyrene Content in Medicinal Herbs

유통 한약재 중 벤조피렌 함량 모니터링 및 안전성 평가

  • Lee, Sae Ram (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Kim, Ae Kyung (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Kim, Sung Dan (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Lee, Hyun Kyung (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Lee, Hee Jin (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Ryu, Hoe Jin (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Lee, Jung Mi (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Yu, In Sil (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Jung, Kweon (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
  • 이새람 (서울시보건환경연구원 한약재검사팀) ;
  • 김애경 (서울시보건환경연구원 한약재검사팀) ;
  • 김성단 (서울시보건환경연구원 한약재검사팀) ;
  • 이현경 (서울시보건환경연구원 한약재검사팀) ;
  • 이희진 (서울시보건환경연구원 한약재검사팀) ;
  • 류회진 (서울시보건환경연구원 한약재검사팀) ;
  • 이정미 (서울시보건환경연구원 한약재검사팀) ;
  • 유인실 (서울시보건환경연구원 한약재검사팀) ;
  • 정권 (서울시보건환경연구원 한약재검사팀)
  • Received : 2017.07.04
  • Accepted : 2017.09.01
  • Published : 2017.09.30
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Abstract

In this study, to investigate of safety for Benzo(a)pyrene in medicinal herb, 8 kinds of selected commercial herbal medicines (Rehmanniae Radix, Rehmanniae Radix Preparata, Amomi Tsao-Ko Fructus, Cimicifugae Rhizoma, Cyperi Rhizoma, Magnoliae Cortex, Scutellariae Radix, Scrophulariae Radix) were analysed using the high performance liquid chromatography with fluorescence detector and assessed the health risk. The levels of benzo(a)pyrene were from non-detection to $28.1{\mu}g/kg$, and the average was $3.6{\mu}g/kg$. Based on a nationwide survey of the consumption of medicinal herb by the Korean population, we estimated the potential risk from the ingestion of benzo(a)pyrene. The estimated daily intake of benzo(a)pyrene was 1.6 ng/kg b.w./day for group only know the daily average intake of medicinal herb. The MOE (margin of exposure) of benzo(a)pyrene for estimate of health risk was $1.93{\times}10^5$. Therefore, health risk from benzo(a)pyrene through intake of herbal medicine was considered negligible.

Keywords

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