생약학회지 (Korean Journal of Pharmacognosy)

  • 제48권3호
  • /
  • Pages.213-218
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  • 2017
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

패독산류의 구강편평세포암종 및 악성중피종에 대한 항암 활성

Anticancer Effect of Paedoksans for Oral Squamous Cell Carcinoma and Malignant Pleural Mesothelioma

  • 오하나 (목포대학교 약학대학 천연약물연구소) ;
  • 김현정 (목포대학교 약학대학 천연약물연구소) ;
  • 채정일 (전북대학교 치의학대학원 치과약리학교실(BK21 플러스사업단)) ;
  • 심정현 (목포대학교 약학대학 천연약물연구소) ;
  • 윤구 (목포대학교 약학대학 천연약물연구소)
  • Oh, Ha-Na (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Kim, Hyun-Jung (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Chae, Jung-Il (Department of Dental Pharmacology, School of Dentistry and Institute of Oral Bioscience, BK21 Plus, Chonbuk National University) ;
  • Shim, Jung-Hyun (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Yoon, Goo (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University)
  • 투고 : 2017.09.05
  • 심사 : 2017.09.20
  • 발행 : 2017.09.30
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초록

In order to search for anticancer agent as therapy of oral squamous cell carcinoma (OSCC) and malignant pleural mesothelioma (MPM) from Korean traditional prescriptions, we selected 58 traditional prescriptions based on a review of the Korean traditional medicine books. Among the selected traditional prescriptions, only water extracts of paedoksan (敗毒散) showed relatively good cytotoxicity at the concentration of $50{\mu}g/ml$. Additionally, we evaluated cytotoxicity for various paedoksans and each herbal ingredient in paedoksans. The root of Anthriscus sylvestris exhibited more cytotoxic effect than any other ingredients in paedoksans. Bioactivity-guided fractionation of the MC layer of Anthriscus sylvestris led to the isolation of deoxypodophyllotoxin (DPT). DPT exhibited dose-dependently significant cytotoxicity against OSCC and MPM cell with nM range. Therefore, DPT from A. sylvestris might be a potential candidate as an effective anticancer therapeutic agent for OSCC and MPM.

키워드

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