DOI QR코드

DOI QR Code

Nonsyndromic Multiple Basal Cell Carcinomas

  • Kim, Dong Hwi (Department of Plastic and Reconstructive Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Ko, Hyo Sun (Department of Plastic and Reconstructive Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Jun, Young Joon (Department of Plastic and Reconstructive Surgery, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • 투고 : 2017.06.13
  • 심사 : 2017.09.08
  • 발행 : 2017.09.20

초록

Basal cell carcinoma (BCC) comprising several lesions is not uncommon, but nonsyndromic multiple BCCs with parotid invasion are rare entities. We present two cases of multiple sporadic, nonsyndromic BCCs, and one of these cases is a unique case of parotid invasion associated purely with actinic keratosis. In Case 1, a 79-year-old female presented with multiple skin lesions on the face and left hand. All lesions were completely removed by surgery. The pathologic results showed lesions consistent with BCC and some lesions consistent with actinic keratosis. After 8 months, the patient presented with skin lesions in bilateral temporal areas and left cheek area. Surgical excision of the lesions was performed, and the biopsy results were squamous cell carcinoma in situ and actinic keratosis. In Case 2, a 43-year-old woman presented with multiple skin lesions on the face, scalp, right chest, abdomen and right leg. All lesions were completely removed by surgery. Pathologic evaluation confirmed the diagnosis of BCC. BCC is rarely metastatic, but it can lead to severe disfiguration or destruction. It is important to diagnose and treat BCC at an early stage.

키워드

참고문헌

  1. Zak-Prelich M, Narbutt J, Sysa-Jedrzejowska A. Environmental risk factors predisposing to the development of basal cell carcinoma. Dermatol Surg 2004;30(2 Pt 2):248-52. https://doi.org/10.1111/j.1524-4725.2004.30089.x
  2. McNaughton SA, Marks GC, Green AC. Role of dietary factors in the development of basal cell cancer and squamous cell cancer of the skin. Cancer Epidemiol Biomarkers Prev 2005;14:1596-607.
  3. Alghamdi Y. Skin tags as a presenting sign of basal cell nevus syndrome in three sisters of the same family. Ann Saudi Med 2008;28:132-4.
  4. Lu Y, Zhu HG, Ye WM, Zhang MB, He D, Chen WT. A new mutation of PTCH gene in a Chinese family with nevoid basal cell carcinoma syndrome. Chin Med J (Engl) 2008;121:118-21.
  5. Farley RL, Manolidis S, Ratner D. Aggressive basal cell carcinoma with invasion of the parotid gland, facial nerve, and temporal bone. Dermatol Surg 2006;32:307-15.
  6. Christensen KN, Henderson GP, Hocker TL, Otley CC, Roenigk RK. Outcomes of basal cell carcinomas directly invading the parotid gland. Dermatol Surg 2015;41:390-6.
  7. Robinson JK. Risk of developing another basal cell carcinoma: a 5-year prospective study. Cancer 1987;60:118-20.
  8. Lara F, Santamaria JR, Garbers LE. Recurrence rate of basal cell carcinoma with positive histopathological margins and related risk factors. An Bras Dermatol 2017;92:58-62.
  9. Happle R. Nonsyndromic type of hereditary multiple basal cell carcinoma. Am J Med Genet 2000;95:161-3.
  10. Ahn SK, Lee HS, Han SK, Lee SH, Lee S. Multiple basal cell carcinoma associated with keratoacanthoma. Yonsei Med J 1992;33:277-80.
  11. Malhotra AK, Gupta S, Khaitan BK, Verma KK. Multiple basal cell carcinomas in xeroderma pigmentosum treated with imiquimod 5% cream. Pediatr Dermatol 2008;25:488-91.
  12. Ramachandran S, Lear JT, Ramsay H, Smith AG, Bowers B, Hutchinson PE, et al. Presentation with multiple cutaneous basal cell carcinomas: association of glutathione S-transferase and cytochrome P450 genotypes with clinical phenotype. Cancer Epidemiol Biomarkers Prev 1999;8:61-7.
  13. Maydan E, Desciak EB, Eliezri YD. Management of cutaneous neoplasms invading the parotid gland. Dermatol Surg 2006;32:1209-13.
  14. Bath-Hextall FJ, Perkins W, Bong J, Williams HC. Interventions for basal cell carcinoma of the skin. Cochrane Database Syst Rev 2007;(1):CD003412.
  15. Cowey CL. Targeted therapy for advanced Basal-cell carcinoma: vismodegib and beyond. Dermatol Ther (Heidelb) 2013;3:17-31.

피인용 문헌

  1. Multiple nonmelanocytic skin cancers in multiple regions vol.21, pp.3, 2020, https://doi.org/10.7181/acfs.2020.00073
  2. Unexpected case of non-syndromic neighbouring basal cell carcinomas vol.13, pp.12, 2017, https://doi.org/10.1136/bcr-2020-240037