DOI QR코드

DOI QR Code

Nontuberculous mycobacterial infection in rheumatoid arthritis patients: a single-center experience in South Korea

  • Lim, Doo-Ho (Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Yong-Gil (Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Shim, Tae Sun (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jo, Kyung-Wook (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ghang, Byeongzu (Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ahn, Soo Min (Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Hong, Seokchan (Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Chang-Keun (Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Yoo, Bin (Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 투고 : 2015.10.29
  • 심사 : 2015.12.14
  • 발행 : 2017.11.01

초록

Background/Aims: Nontuberculous mycobacteria (NTM) infection has been increasing worldwide in both general population and immunocompromised patients, which has also been reported in rheumatoid arthritis (RA) patients. This study aimed to identify the incidence and clinical characteristics of NTM infection in RA patients living in tuberculosis (TB) infection endemic area. Methods: We performed a retrospective analysis of NTM infection cases in our RA registry at a tertiary referral center from January 1995 to December 2013. The clinical features of them were compared to those of 52 TB infection patients from same registry. Results: Among 1,397 patients with RA, NTM infection was newly developed in 26 patients and the incidence of NTM infection was 164.8 per 100,000 patient-years. The Mycobacterium avium complex was the most frequent isolate (76.9%). None of the NTM infections had extrapulmonary involvement, which was rather common in TB infection (26.9%). Patients with NTM infection were older, received higher cumulative steroid doses, and had higher rates of past TB infection history and concomitant interstitial lung disease (ILD) than cases with TB infection. Conclusions: In South Korea, NTM infection is not rare in RA patients, and infection rates are growing. Physicians should be cautious about NTM infection in patients with a history of TB infection or concomitant ILD, even living in TB endemic area.

키워드

과제정보

연구 과제 주관 기관 : Asan Institute for Life Science

참고문헌

  1. Iseman MD. Mycobacterial infections in the era of modern biologic agents. Am J Med Sci 2011;341:278-280. https://doi.org/10.1097/MAJ.0b013e31820f8c70
  2. Falkinham JO. Impact of human activities on the ecology of nontuberculous mycobacteria. Future Microbiol 2010;5:951-960. https://doi.org/10.2217/fmb.10.53
  3. Zumla A, Grange J. Infection and disease caused by environmental mycobacteria. Curr Opin Pulm Med 2002;8:166-172. https://doi.org/10.1097/00063198-200205000-00003
  4. Henkle E, Winthrop KL. Nontuberculous mycobacteria infections in immunosuppressed hosts. Clin Chest Med 2015;36:91-99. https://doi.org/10.1016/j.ccm.2014.11.002
  5. Doran MF, Crowson CS, Pond GR, O'Fallon WM, Gabriel SE. Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based study. Arthritis Rheum 2002;46:2287-2293. https://doi.org/10.1002/art.10524
  6. Wolfe F, Mitchell DM, Sibley JT, et al. The mortality of rheumatoid arthritis. Arthritis Rheum 1994;37:481-494. https://doi.org/10.1002/art.1780370408
  7. Baum J. Infection in rheumatoid arthritis. Arthritis Rheum 1971;14:135-137. https://doi.org/10.1002/art.1780140119
  8. Brode SK, Jamieson FB, Ng R, et al. Risk of mycobacterial infections associated with rheumatoid arthritis in Ontario, Canada. Chest 2014;146:563-572. https://doi.org/10.1378/chest.13-2058
  9. Winthrop KL, Baxter R, Liu L, et al. Mycobacterial diseases and antitumour necrosis factor therapy in USA. Ann Rheum Dis 2013;72:37-42. https://doi.org/10.1136/annrheumdis-2011-200690
  10. Winthrop KL, Chang E, Yamashita S, Iademarco MF, LoBue PA. Nontuberculous mycobacteria infections and anti-tumor necrosis factor-alpha therapy. Emerg Infect Dis 2009;15:1556-1561. https://doi.org/10.3201/eid1510.090310
  11. Yoo JW, Jo KW, Kang BH, et al. Mycobacterial diseases developed during anti-tumour necrosis factor-${\alpha}$ therapy. Eur Respir J 2014;44:1289-1295. https://doi.org/10.1183/09031936.00063514
  12. Mori S, Tokuda H, Sakai F, et al. Radiological features and therapeutic responses of pulmonary nontuberculous mycobacterial disease in rheumatoid arthritis patients receiving biological agents: a retrospective multicenter study in Japan. Mod Rheumatol 2012;22:727-737. https://doi.org/10.3109/s10165-011-0577-6
  13. Wallis RS, Broder MS, Wong JY, Hanson ME, Beenhouwer DO. Granulomatous infectious diseases associated with tumor necrosis factor antagonists. Clin Infect Dis 2004;38:1261-1265. https://doi.org/10.1086/383317
  14. Griffith DE, Aksamit T, Brown-Elliott BA, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007;175:367-416. https://doi.org/10.1164/rccm.200604-571ST
  15. Eurosurveillance editorial team. WHO revised definitions and reporting framework for tuberculosis. Euro Surveill 2013;18:20455.
  16. Yamakawa H, Takayanagi N, Miyahara Y, et al. Prognostic factors and radiographic outcomes of nontuberculous mycobacterial lung disease in rheumatoid arthritis. J Rheumatol 2013;40:1307-1315. https://doi.org/10.3899/jrheum.121347
  17. Adjemian J, Olivier KN, Seitz AE, Holland SM, Prevots DR. Prevalence of nontuberculous mycobacterial lung disease in U.S. Medicare beneficiaries. Am J Respir Crit Care Med 2012;185:881-886. https://doi.org/10.1164/rccm.201111-2016OC
  18. Prevots DR, Marras TK. Epidemiology of human pulmonary infection with nontuberculous mycobacteria: a review. Clin Chest Med 2015;36:13-34. https://doi.org/10.1016/j.ccm.2014.10.002
  19. Eurosurveillance editorial team. WHO publishes global tuberculosis report 2013. Euro Surveill 2013;18;20615.
  20. Park YS, Lee CH, Lee SM, et al. Rapid increase of non-tuberculous mycobacterial lung diseases at a tertiary referral hospital in South Korea. Int J Tuberc Lung Dis 2010;14:1069-1071.
  21. Lee SK, Lee EJ, Kim SK, Chang J, Jeong SH, Kang YA. Changing epidemiology of nontuberculous mycobacterial lung disease in South Korea. Scand J Infect Dis 2012;44:733-738. https://doi.org/10.3109/00365548.2012.681695
  22. Marras TK, Chedore P, Ying AM, Jamieson F. Isolation prevalence of pulmonary non-tuberculous mycobacteria in Ontario, 1997 2003. Thorax 2007;62:661-666. https://doi.org/10.1136/thx.2006.070797
  23. Andrejak C, Thomsen VO, Johansen IS, et al. Nontuberculous pulmonary mycobacteriosis in Denmark: incidence and prognostic factors. Am J Respir Crit Care Med 2010;181:514-521. https://doi.org/10.1164/rccm.200905-0778OC
  24. Prevots DR, Shaw PA, Strickland D, et al. Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems. Am J Respir Crit Care Med 2010;182:970-976. https://doi.org/10.1164/rccm.201002-0310OC
  25. Tanoue LT. Pulmonary manifestations of rheumatoid arthritis. Clin Chest Med 1998;19:667-685. https://doi.org/10.1016/S0272-5231(05)70109-X
  26. Marras TK, Mehta M, Chedore P, May K, Al Houqani M, Jamieson F. Nontuberculous mycobacterial lung infections in Ontario, Canada: clinical and microbiological characteristics. Lung 2010;188:289-299. https://doi.org/10.1007/s00408-010-9241-8
  27. Park SW, Song JW, Shim TS, et al. Mycobacterial pulmonary infections in patients with idiopathic pulmonary fibrosis. J Korean Med Sci 2012;27:896-900. https://doi.org/10.3346/jkms.2012.27.8.896
  28. van Ingen J, Hoefsloot W, Dekhuijzen PN, Boeree MJ, van Soolingen D. The changing pattern of clinical Mycobacterium avium isolation in the Netherlands. Int J Tuberc Lung Dis 2010;14:1176-1180.
  29. Chuang HC, Su CL, Liu HC, et al. Cigarette smoke is a risk factor for severity and treatment outcome in patients with culture-positive tuberculosis. Ther Clin Risk Manag 2015;11:1539-1544.
  30. Lan R, Yang C, Lan L, et al. Mycobacterium tuberculosis and non-tuberculous mycobacteria isolates from HIV-infected patients in Guangxi, China. Int J Tuberc Lung Dis 2011;15:1669-1675. https://doi.org/10.5588/ijtld.11.0036
  31. Falkinham JO 3rd. Epidemiology of infection by nontuberculous mycobacteria. Clin Microbiol Rev 1996;9:177-215. https://doi.org/10.1128/CMR.9.2.177
  32. Martin-Casabona N, Bahrmand AR, Bennedsen J, et al. Non-tuberculous mycobacteria: patterns of isolation. A multi-country retrospective survey. Int J Tuberc Lung Dis 2004;8:1186-1193.
  33. O'Brien RJ, Geiter LJ, Snider DE Jr. The epidemiology of nontuberculous mycobacterial diseases in the United States. Results from a national survey. Am Rev Respir Dis 1987;135:1007-1014.
  34. Tsukamura M, Kita N, Shimoide H, Arakawa H, Kuze A. Studies on the epidemiology of nontuberculous mycobacteriosis in Japan. Am Rev Respir Dis 1988;137:1280-1284. https://doi.org/10.1164/ajrccm/137.6.1280
  35. Koh WJ, Kwon OJ, Jeon K, et al. Clinical significance of nontuberculous mycobacteria isolated from respiratory specimens in Korea. Chest 2006;129:341-348. https://doi.org/10.1378/chest.129.2.341
  36. Ryoo SW, Shin S, Shim MS, et al. Spread of nontuberculous mycobacteria from 1993 to 2006 in Koreans. J Clin Lab Anal 2008;22:415-420. https://doi.org/10.1002/jcla.20278
  37. Henry MT, Inamdar L, O'Riordain D, Schweiger M, Watson JP. Nontuberculous mycobacteria in non-HIV patients: epidemiology, treatment and response. Eur Respir J 2004;23:741-746. https://doi.org/10.1183/09031936.04.00114004
  38. Huang YC, Liu MF, Shen GH, et al. Clinical outcome of Mycobacterium abscessus infection and antimicrobial susceptibility testing. J Microbiol Immunol Infect 2010;43:401-406. https://doi.org/10.1016/S1684-1182(10)60063-1
  39. Kim EY, Chi SY, Oh IJ, et al. Treatment outcome of combination therapy including clarithromycin for Mycobacterium avium complex pulmonary disease. Korean J Intern Med 2011;26:54-59. https://doi.org/10.3904/kjim.2011.26.1.54

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