The Korean journal of internal medicine

  • 제32권6호
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  • Pages.1062-1068
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  • 2017
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study

  • Bae, Eun Hui (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Kim, Jong Woon (Department of Obsterics, Chonnam National University Medical School) ;
  • Choi, Hong Sang (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Ma, Seong Kwon (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Kim, Soo Wan (Department of Internal Medicine, Chonnam National University Medical School)
  • 투고 : 2016.01.07
  • 심사 : 2016.05.06
  • 발행 : 2017.11.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Proteinuria is associated with hypertension and preeclampsia in pregnancy. However, the impact of random urine proteinuria on fetal and maternal outcomes has not been established. We investigated the influence of random urine proteinuria on the clinical outcomes of pregnancy. Methods: From January 2008 to December 2010, 2,822 patients were retrospectively studied. A total of 536 pregnant women with proteinuria in random urine and matched controls without proteinuria via propensity score matching were analyzed. Proteinuria was checked by the dipstick method. Results: The patients' mean age was $33.0{\pm}4.7years$, and the mean gestational age was $235.6{\pm}50.6days$ on admission. The prevalence of hypertension and chronic kidney disease was 2.4% (n = 67) and 1.0% (n = 29), respectively. Women with random urine proteinuria showed higher blood urea nitrogen levels and a higher incidence of hematuria. These women also had a higher incidence of preeclampsia, preterm labor, premature rupture of membranes, and intrauterine growth restriction. Proteinuria was strongly correlated with preeclampsia in both propensity score matching (p < 0.001, r = 0.783) and unmatched whole samples (p < 0.001, r = 0.851). Conclusions: These findings suggest that random urine proteinuria is associated with preeclampsia, preterm labor, premature rupture of membrane, and intrauterine growth restriction.

키워드

과제정보

연구 과제 주관 기관 : National Research Foundation of Korea (NRF)

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피인용 문헌

  1. A simple pregnancy-related kidney disease screening method: random proteinuria testing vol.32, pp.6, 2017, https://doi.org/10.3904/kjim.2017.341
  2. The Association Between GFR Evaluated by Serum Cystatin C and Proteinuria During Pregnancy vol.4, pp.6, 2019, https://doi.org/10.1016/j.ekir.2019.04.004
  3. Gestational hypertension and pre‐eclampsia and risk of spontaneous premature rupture of membranes: A population‐based cohort study vol.147, pp.2, 2017, https://doi.org/10.1002/ijgo.12943