The Korean journal of internal medicine

  • 제32권6호
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  • Pages.1045-1052
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  • 2017
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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DOI QR코드

DOI QR Code

p22phox C242T gene polymorphism and overt diabetic nephropathy: a meta-analysis of 1,452 participants

  • Li, Yan-yan (Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University) ;
  • Gong, Ge (Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University) ;
  • Geng, Hong-yu (Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University) ;
  • Qian, Yun (Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University)
  • 투고 : 2015.04.18
  • 심사 : 2015.07.20
  • 발행 : 2017.11.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: The p22phox C242T gene polymorphism (rs4673) may be linked to an increased susceptibility for overt diabetic nephropathy (ODN), but the study results are still inconclusive. Methods: To explore the relationship between p22phox C242T gene polymorphism and ODN, the current meta-analysis of 707 ODN patients and 745 controls from five individual studies was conducted. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) were evaluated by either a random or fixed effect model. Results: In our meta-analysis, a significant relationship between the p22phox C242T gene polymorphism and ODN was found under allelic (OR, 2.760; 95% CI, 1.400 to 5.450; p = 0.004), recessive (OR, 5.080; 95% CI, 1.020 to 25.430; p = 0.05), dominant (OR, 1.700; 95% CI, 1.167 to 2.477; p = 0.006), homozygous (OR, 3.900; 95% CI, 1.022 to 14.889; p = 0.046), heterozygous (OR, 1.523; 95% CI, 1.167 to 1.986; p = 0.002), and additive genetic models (OR, 2.019; 95% CI, 1.232 to 3.309; p = 0.005). Conclusions: A positive correlation between p22phox C242T gene polymorphism and ODN risk was found. The T allele carriers of p22phox C242T gene polymorphism might be predisposed to ODN.

키워드

과제정보

연구 과제 주관 기관 : National Natural Science Foundation of China, Nanjing Medical University

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