The Korean journal of internal medicine

  • 제32권6호
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  • Pages.1010-1017
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  • 2017
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Clinical implication of serum uric acid level in pegylated interferon and ribavirin combination therapy for chronic hepatitis C infection

  • Oh, In Soo (Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Won, Joung Won (Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Kim, Hyung Joon (Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Lee, Hyun Woong (Department of Internal Medicine, Chung-Ang University College of Medicine)
  • 투고 : 2016.12.06
  • 심사 : 2017.05.22
  • 발행 : 2017.11.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Combined treatment of pegylated $interferon-{\alpha}$ (PEG-IFN) and ribavirin (RBV) has long been accepted as the standard treatment for chronic hepatitis C virus (HCV) infection. Many predictive factors for treatment response have been identified. The aim of this study was to evaluate the efficacy and safety of combined PEG-IFN plus RBV and to examine the value of serum uric acid as a predictive factor in the treatment of chronic hepatitis C. Methods: A total of 74 patients chronically infected with HCV were enrolled between December 2004 and June 2009. Patients received subcutaneous PEG-IFN (${\alpha}-2a$: $180{\mu}g$ once a week) in combination with RBV (1,000 to 1,200 mg daily depending on body weight). We evaluated treatment responses represented by early virologic response (EVR), end-of-treatment response (ETR), sustained virologic response (SVR), and relapse, as well as diverse adverse events. Various viral and host features were also assessed to clarify factors associated with treatment response. Results: During treatment, EVR was achieved in 26 patients (26/33, 78.8%) with HCV genotype 1. ETR and SVR were achieved in 59 (77.6%) and 56 patients (73.6%), respectively, across all genotypes. Genotype 2/3, lower HCV RNA, and lower uric acid were associated with higher SVR. Conclusions: The treatment response to combination therapy with PEG-IFN plus RBV was effective, especially in genotype 2/3. Uric acid might be useful as a predictive factor for response to therapy for chronic hepatitis.

키워드

참고문헌

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