The Korean journal of internal medicine

  • 제32권4호
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  • Pages.711-721
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  • 2017
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Myeloma prognostic index at diagnosis might be a prognostic marker in patients newly diagnosed with multiple myeloma

  • Kim, Dae Sik (Division of Oncology and Hematology, Department of Internal Medicine, Korea University School of Medicine) ;
  • Yu, Eun Sang (Division of Oncology and Hematology, Department of Internal Medicine, Korea University School of Medicine) ;
  • Kang, Ka-Won (Division of Oncology and Hematology, Department of Internal Medicine, Korea University School of Medicine) ;
  • Lee, Se Ryeon (Division of Oncology and Hematology, Department of Internal Medicine, Korea University School of Medicine) ;
  • Park, Yong (Division of Oncology and Hematology, Department of Internal Medicine, Korea University School of Medicine) ;
  • Sung, Hwa Jung (Division of Oncology and Hematology, Department of Internal Medicine, Korea University School of Medicine) ;
  • Choi, Chul Won (Division of Oncology and Hematology, Department of Internal Medicine, Korea University School of Medicine) ;
  • Kim, Byung Soo (Division of Oncology and Hematology, Department of Internal Medicine, Korea University School of Medicine)
  • 투고 : 2016.03.01
  • 심사 : 2016.04.17
  • 발행 : 2017.07.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: The aims of this study were to identify the value of inflammatory markers as pretreatment prognostic factors for patients with multiple myeloma (MM) and to estimate the value of a prognostic index including these markers at diagnosis. Methods: A total of 273 newly diagnosed MM patients undergoing active treatment were analyzed in this study. The prognostic values for survival of the pretreatment inflammatory markers were investigated. A myeloma prognostic index (MPI) was derived using prognostic factors determined to be independently significant on multivariate analysis. Results: A high pretreatment neutrophil-lymphocyte ratio (NLR), low platelet count, and high C-reactive protein (CRP) level had independently unfavorable significance for overall survival (OS). The MPI was derived based on these factors. Per the MPI, 1 point each was assigned to high NLR, low platelet count, and high CRP. Risk categories were stratified into low- (score 0), intermediate- (score 1), and high-risk (score 2 or 3) groups. The MPI demonstrated independent statistical significance for OS on multivariate analysis ([intermediate: hazard ratio (HR), 1.91; 95% confidence interval (CI), 1.12 to 3.24] and [high: HR, 3.37; 95% CI, 2.00 to 5.69]; p < 0.001). Moreover, this significance could be observed regardless of age, renal function, and exposure to novel agents. In addition, the International Staging System risk group could be further significantly stratified using the MPI. Conclusions: The MPI, consisting of pretreatment inflammatory markers, NLR, platelet count, and CRP, might be effective in predicting the survival of newly diagnosed MM patients undergoing active treatment.

키워드

과제정보

연구 과제 주관 기관 : Korea Health Industry Development Institute (KHIDI)

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  5. Validation of the UK myeloma research alliance risk profile, a new clinical prediction model for outcome in patients with newly diagnosed multiple myeloma not eligible for autologous stem cell transpl vol.193, pp.1, 2017, https://doi.org/10.1111/bjh.16806