The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Ultrasound-guided percutaneous portal transplantation of peripheral blood monocytes in patients with liver cirrhosis

  • Yu, Su Jong (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine) ;
  • Yoon, Jung-Hwan (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine) ;
  • Kim, Won (Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center) ;
  • Lee, Jeong Min (Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine) ;
  • Lee, Yun Bin (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine) ;
  • Cho, Yuri (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine) ;
  • Lee, Dong Hyeon (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine) ;
  • Lee, Minjong (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine) ;
  • Yoo, Jeong-Ju (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine) ;
  • Cho, Eun Ju (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine) ;
  • Lee, Jeong-Hoon (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine) ;
  • Kim, Yoon Jun (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine) ;
  • Kim, Chung Yong (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine)
  • Received : 2015.08.11
  • Accepted : 2015.09.06
  • Published : 2017.03.01
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Abstract

Background/Aims: Liver transplantation offers the only definite cure for cirrhosis but lacking donors is problem. Stem cell therapy is attractive in this setting. In this study, we aimed to explore the safety and efficacy of ultrasound-guided percutaneous portal transplantation of peripheral blood monocyte cell (PBMC) in cirrhotic patients. Methods: A total of nine decompensated cirrhotic patients were randomized into three groups: group 1 (n = 3) was control group, group 2 (n = 3) received granulocyte-colony stimulating factor (G-CSF) mobilization for 3 days, and group 3 (n = 3) received G-CSF mobilized PBMCs by leukapheresis and PBMC transplantation through ultrasound-guided percutaneous portal vein puncture. Liver function and clinical features were evaluated. Results: At baseline, the Child-Turcotte-Pugh and the model for end-stage liver disease scores were comparable in study groups. Compared with group 1, there was a tendency to improve liver function in group 3 at 6 months after treatment. Treatment was tolerable and no complications were encountered related to the G-CSF mobilization or percutaneous portal administration of PBMCs. Imaging studies showed patent portal veins at the end of the study period. Conclusions: Autologous PBMC transplantation through ultrasound-guided percutaneous portal vein puncture could be considered as a safe alternative treatment for decompensated cirrhotic patients.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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