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AMD Identification from OCT Volume Data using Deep Convolutional Neural Network

심층 컨볼루션 신경망을 이용한 OCT 볼륨 데이터로부터 AMD 진단

  • Kwon, Oh-Heum (Dept. of IT Convergence and Application, Pukyong National University) ;
  • Jung, Yoo Jin (Division of Computer & Electronic Systems Engineering, Hankuk University of Foreign Studies) ;
  • Song, Ha-Joo (Dept. of IT Convergence and Application, Pukyong National University)
  • Received : 2017.07.17
  • Accepted : 2017.08.01
  • Published : 2017.08.31

Abstract

Optical coherence tomography (OCT) is the most common medical imaging device with the ability to image the retina in eyes at micrometer resolution and to visualize the pathological indicators of many retinal diseases such as Age-Related Macular Degeneration (AMD) and diabetic retinopathy. Accordingly, there have been research activities to analyze and process OCT images to identify those indicators and make medical decisions based on the findings. In this paper, we use a deep convolutional neural network for analysis of OCT volume data to distinguish AMD from normal patients. We propose a novel approach where images in each OCT volume are grouped together into sub-volumes and the network is trained by those sub-volumes instead of individual images. We conducted an experiment using public data set to evaluate the performance of the proposed approach. The experiment confirmed performance improvement of our approach over the traditional image-by-image training approach.

Keywords

References

  1. J. Welzel, “Optical Coherence Tomography in Dermatology : A Review,” Skin Research and Technology, Vol. 7, No. 1, pp. 1-9, 2001. https://doi.org/10.1034/j.1600-0846.2001.007001001.x
  2. S.J. Chiu, J.A. Izatt, R.V. O'Connell, K.P. Winter, C.A. Toth, and S. Farsiu, "Validated Automatic Segmentation of AMD Pathology Including Drusen and Geographic Atrophy in SD-OCT Images," Investigative Ophthalmology and Visual Science, Vol. 53, No. 1, pp. 53-61, 2012. https://doi.org/10.1167/iovs.11-7640
  3. G. Lemaitre, M. Rastgoo, J. Massich, C.Y. Cheung, Y. Wong, E. Lamoureux, et al., "Classification of SD-OCT Volumes Using Local Binary Patterns: Experimental Validation for DME Detection," Journal of Ophthalmology, Vol. 6, pp. 1-16, 2016.
  4. Y. Liu, M. Chen, H. Ishikawa, G. Wollstein, J.S. Schuman, and J.M. Rehg, "Automated Macular Pathology Diagnosis in Retinal OCT Images Using Multi-scale Spatial Pyramid with Local Binary Patterns," Proceeding of Medical Image Computing and Computer-Assisted Intervention, pp. 1-9, 2010.
  5. S. Lim and D.Y. Kim, "Object Tracking Using Feature Map from Convolutional Neural Network," Journal of Korea Multimedia Society, Vol. 20, No. 2, pp. 126-13, 2017. https://doi.org/10.9717/kmms.2017.20.2.126
  6. A. Krizhevsky, I. Sutskever, and G.E. Hinton, "ImageNet: Classification with Deep Convolutional Neural Networks," Proceeding of the 25th International Conference on Neural Information Processing Systems, pp. 1097-1105, 2012.
  7. J.T. Lee, H. Kang, and K. Lim, "Moving Shadow Detection Using Deep Learning and Markov Random Field," Journal of Korea Multimedia Society, Vol. 18, No. 12, pp. 1432-1438, 2015. https://doi.org/10.9717/kmms.2015.18.12.1432
  8. M.D. Abramoff, Y. Lou, and A. Erginay, “Improved Automated Detection of Diabetic Retinopathy on a Publicly Available Dataset Through Integration of Deep Learning,” Investigative Ophthalmology and Visual Science, Vol. 57, No. 13, pp. 5200-5206, 2016. https://doi.org/10.1167/iovs.16-19964
  9. R. Asaoka, H. Murata, A. Iwase, and M. Araie, “Detecting Preperimetric Glaucoma with Standard Automated Primetry Using a Deep Learning Classifier,” Ophthalmology, Vol. 123, No. 9, pp. 1974-1980, 2016. https://doi.org/10.1016/j.ophtha.2016.05.029
  10. S. Apostolopoulos, C. Ciller, S. De Zanet, S. Wolf, and R. Sznitman, "RetiNet: Automatic AMD Identification in OCT Volumetric Data," arXiv:1610.03628, 2016.
  11. T. Schlegl, S.M. Waldstein, U.M. Schmidt-Erfurth, and G. Langs, "Predicting Semantic Descriptions from Medical Images with Convolutional Neural Networks," Information Processing in Medical Imaging, Vol. 24, pp. 437-448, 2015.
  12. S. Cecilia, M.D. Lee, D.M. Baughman, and Y. Aaron, "Deep Learning is Effective for Classifying Normal Versus Age-related Macular Degeneration Optical Coherence Tomography Images," arXiv:1612.04891, 2016.
  13. K. Simonyan and A. Zisserman, "Very Deep Convolutional Networks for Large-scale Image Recognition," arXiv:1409.1556, 2014.
  14. S. Farsiu, S.J. Chiu, R.V. O'Connell, F.A. Folgar, E. Yuan, J.A. Izatt, et al., "Quantitative Classification of Eyes with and without Intermediate Age-related Macular Degeneration Using Optical Coherence Tomography," Ophthalmology, Vol. 121, No. 1, pp. 162-172, 2014. https://doi.org/10.1016/j.ophtha.2013.07.013