Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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The Association of the 2nd to 4th Digit Ratio with the Age of Onset and Metabolic Factors in Korean Patients with Schizophrenia

한국 조현병 환자에서 검지-약지 길이비와 발병 연령 및 대사 장애와의 연관성

  • Kim, Hong Rae (Department of Psychiatry, Hanyang University Guri Hospital) ;
  • Lee, Jung Sun (Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Joo, Yeon Ho (Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Won, Seunghee (Department of Psychiatry, Kyungpook National University School of Medicine) ;
  • Ryu, Seunghyong (Department of Mental Health Research, National Center for Mental Health) ;
  • Hong, Kyung Sue (Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Kwon, Jun Soo (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Lee, Seung Yeoun (Department of Statistics, Sejong University) ;
  • Oh, Hong Seok (Department of Psychiatry, Yong-In Mental Hospital) ;
  • Choi, Joon Ho (Department of Psychiatry, Hanyang University Guri Hospital) ;
  • Lee, Yu Sang (Department of Psychiatry, Yong-In Mental Hospital)
  • 김홍래 (한양대학교 구리병원 정신건강의학과) ;
  • 이중선 (울산대학교 의과대학 서울아산병원 정신건강의학교실) ;
  • 주연호 (울산대학교 의과대학 서울아산병원 정신건강의학교실) ;
  • 원승희 (경북대학교 의학전문대학원 정신건강의학교실) ;
  • 류승형 (국립정신건강센터 정신보건연구과) ;
  • 홍경수 (성균관대학교 의과대학 삼성서울병원 정신건강의학교실) ;
  • 권준수 (서울대학교 의과대학 정신건강의학교실) ;
  • 이승연 (세종대학교 수학통계학부) ;
  • 오홍석 (용인정신병원) ;
  • 최준호 (한양대학교 구리병원 정신건강의학과) ;
  • 이유상 (용인정신병원)
  • Received : 2017.07.07
  • Accepted : 2017.07.24
  • Published : 2017.08.31
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Abstract

Objectives The ratio of second to fourth digit length (2D : 4D) could be a potential epigenetic marker of sexual dimorphism reflecting prenatal testosterone exposure. Testosterone is known to affect the development of the brain through an epigenetic mechanism. The purpose of this study was to investigate the effects of exposure to fetal testosterone on the metabolic syndrome based on 2D : 4D of schizophrenia patients and the relationship with the age of onset of schizophrenia. Methods A total of 214 schizophrenia patients participated in this study. The participant's physical and blood tests were performed according to the American National Cholesterol Education Program's Third Amendment of the Metabolic Syndrome Diagnostic Criteria, and the 2D : 4D was measured by the method designed by McFadden. Data were statistically analyzed by t-test, Pearson's correlation analysis and multiple regression model analysis. Results 2D : 4D was significantly higher in female than male in both hands, and there was a statistically significant negative correlation between 2D : 4D and the age of onset of schizophrenia in male. However, 2D : 4D did not show statistically significant correlation with metabolic factors. Conclusions Fetal testosterone suggests the possibility of affecting the age of onset of schizophrenia through the epigenetic mechanism, but there is no clear relationship with metabolic factors.

Keywords

References

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