Acknowledgement
Supported by : 한국연구재단
Korean Journal of Dental Materials (대한치과재료학회지)
- Volume 44 Issue 1
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- Pages.33-41
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- 2017
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- 2384-4434(pISSN)
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- 2384-3268(eISSN)
DOI QR Code
In vivo evaluation of infrared LASER mediated drug release of PLA-tetracycline complexes coated gold nanoparticle-titania nanotubes with mouse
마우스를 이용한 PLA - tetracycline 복합체 코팅 금 나노입자 - 티타니아 나노튜브의 적외선 레이저 유도 약물용출 생체 내 평가
- Moon, Kyung-Suk (Department of Dental Biomaterials and the Institute of Biomaterial.Implant, College of Dentistry, Wonkwang University) ;
- Jeoung, Chan-Gwoun (Department of Electronic Engineering, College of Creative Engineering, Wonkwang University) ;
- Bae, Ji-Myung (Department of Dental Biomaterials and the Institute of Biomaterial.Implant, College of Dentistry, Wonkwang University) ;
- Oh, Seunghan (Department of Dental Biomaterials and the Institute of Biomaterial.Implant, College of Dentistry, Wonkwang University)
- 문경숙 (원광대학교 치과대학 치과생체재료학교실 및 생체재료.매식 연구소) ;
- 정찬권 (원광대학교 창의공과대학 전자공학과) ;
- 배지명 (원광대학교 치과대학 치과생체재료학교실 및 생체재료.매식 연구소) ;
- 오승한 (원광대학교 치과대학 치과생체재료학교실 및 생체재료.매식 연구소)
- Received : 2017.02.08
- Accepted : 2017.03.09
- Published : 2017.03.31
Abstract
In this study, we prepared PLA-tetracycline complexes coated gold nanoparticle-titania nanotubes and estimated their infrared LASER mediated drug release in the abdominal region of ICR mouse. The results of UV-Vis spectrophotometer showed the highest absorbance at the wavelength of 530 nm and 809 nm indicating the existence of gold nanoparticles. EDX analysis showed that the amounts of gold nanoparticle coated on titania nanotubes were approximately 3.62-36.5 wt%. In vivo test resulted that the tetracycline release value of experimental groups (6.5 ng/mL) was higher than that of control group (5.8 ng/mL) on the condition of 30 minutes of LASER irradiation. Therefore, it is expected that PLA-tetracycline complexes coated gold nanoparticle-titania nanotubes have the feasibility in the field of infrared remote controlled drug device and overcome the limitation of location and time of drug release in dental implant.