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- Anti-Inflammatory and Immunomodulatory Properties of Fermented Plant Foods vol.13, pp.5, 2021, https://doi.org/10.3390/nu13051516
Toxicology and Environmental Health Sciences
- Volume 9 Issue 5
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- Pages.279-282
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- 2017
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- 2005-9752(pISSN)
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- 2233-7784(eISSN)
DOI QR Code
Anti-inflammatory Effect of Lactic Acid Bacteria Isolated from Kimchi on Acid-induced Acute Colitis in Model Mice
- Lee, Soo Youn (Climate Change Research Division, Korea Institute of Energy Research) ;
- Sekhon, Simranjeet Singh (School of Biological Sciences, Chungbuk National University) ;
- Kim, Hyung Cheol (Technology Transfer Center, Korea Research Institute of Bioscience and Biotechnology) ;
- Won, Kyungho (Pear Research Institute, National Institute of Horticultural & Herbal Science, Rural Development Administration) ;
- Ahn, Ji-Young (School of Biological Sciences, Chungbuk National University) ;
- Lee, Kibeom (Biotechnology & Business Center, Incheon Technopark) ;
- Kim, Yang-Hoon (School of Biological Sciences, Chungbuk National University)
- Received : 2017.08.11
- Accepted : 2017.10.19
- Published : 2017.12.31
Abstract
Lactic acid bacteria (LAB) provide numerous beneficial effects on the host body, especially on the intestine. Two LAB strains isolated from Kimchi, Leuconostoc mesenteroides and Lactobacillus sakei, were studied for its anti-inflammatory activity in acidinduced acute colitis in mice. To induce acute colitis in model mice (C57BL/6), 3% of dextran sulfate sodium treatment was treated for 7 days. Assessment of necropsy and histopathology analysis showed that oral supplementation of both L. mesenteroides and L. sakei ameliorated the symptoms of acute colitis. Moreover, the mixture of L. meseneroides and L. sakei showed synergistic effect on colitis. The results suggest that the formulation of L. mesenteroides and L. sakei mixture could be used as an oral supplementation to decrease the inflammatory harmful environment associated with colitis.