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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Resveratrol Down-regulates Bmi-1 Expression and Inhibits Breast Cancer Cell Growth In Vitro

유방암세포 성장과 Bmi-1 발현에 대한 레스베라트롤의 억제 효과

  • Park, Hyun-Joo (Department of Dental Pharmacology, School of Dentistry, Yangsan Campus of Pusan National University) ;
  • Bak, Kwang Je (Department of Dental Pharmacology, School of Dentistry, Yangsan Campus of Pusan National University) ;
  • Ok, Chang Youp (Department of Life Science in Dentistry, School of Dentistry, Yangsan Campus of Pusan National University) ;
  • Jang, Hye-Ock (Department of Dental Pharmacology, School of Dentistry, Yangsan Campus of Pusan National University) ;
  • Bae, Moon-Kyoung (Department of Oral Physiology, School of Dentistry, Yangsan Campus of Pusan National University) ;
  • Bae, Soo-Kyung (Department of Dental Pharmacology, School of Dentistry, Yangsan Campus of Pusan National University)
  • 박현주 (부산대학교 치의과전문대학원 치의학과 치과약리학교실) ;
  • 박광제 (부산대학교 치의과전문대학원 치의학과 치과약리학교실) ;
  • 옥창엽 (부산대학교 치의과전문대학원 치의생명과학과) ;
  • 장혜옥 (부산대학교 치의과전문대학원 치의학과 치과약리학교실) ;
  • 배문경 (부산대학교 치의과전문대학원 치의학과 구강생리학교실) ;
  • 배수경 (부산대학교 치의과전문대학원 치의학과 치과약리학교실)
  • Received : 2017.08.20
  • Accepted : 2017.09.12
  • Published : 2017.09.30
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Abstract

Resveratrol has been actively investigated as an anticancer drug since it induces cell growth inhibition and apoptosis in many cancer cells. Resveratrol acts through modulation of multiple pathways and genes. In this study, we found resveratrol reduced cell growth and mammosphere formation in MDA-MB-231 triple-negative human breast cancer cells. This suppressive effect of resveratrol is accompanied by a reduction in Bmi-1 gene expression. We also observed that knock-down of Bmi-1 gene by small interfering RNA effectively sensitizes breast cancer cells to resveratrol treatment. Our data demonstrate, for the first time, that resveratrol down-regulates Bmi-1 expression in human breast cancer cells and suggest that specific molecular targeting of Bmi-1 can be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to resveratrol.

Keywords

Acknowledgement

Supported by : 부산대학교

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