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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Inhibitory Effect of Globefish Homogenate on the Growth of Caco-2 Human Colorectal Cancer Cells

복어 균질액의 Caco-2 인간 결장직장암세포 성장 억제 효과에 대한 연구

  • Received : 2017.07.26
  • Accepted : 2017.08.23
  • Published : 2017.09.30
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Abstract

Colorectal cancer is a leading cause of cancer mortality worldwide. Many studies show that most cases of human colorectal cancer arise from adenomatous polyps, which are usually dysplastic, nonmalignant precursor lesions; however, accumulation of multiple somatic mutations leads some to develop into advanced adenoma, which ultimately progresses to an invasive colorectal cancer. Notwithstanding the efforts made to improve chemotherapy, most colorectal cancers are unresponsive to this form of treatment, and malignant colorectal cancers remain incurable. To reduce the incidence of colorectal cancer mortality, further studies to improve colorectal cancer treatment are needed. Here, we show that Globefish homogenate suppresses the growth of Caco-2 human colorectal cancer cells, and that the homogenate inhibits Caco-2 cell proliferation in a dose-dependent manner. These data suggest that Globefish homogenate may suppress colorectal cancer development.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea

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