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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Effects of Rumex axetosella, Sonchus oleraceus and Euphoibia jolkini Extracts on Melanin Synthesis in Melanoma Cells

애기수영, 방가지똥 및 암대극 추출물이 Melanoma Cell에서 멜라닌 합성에 미치는 영향

  • Kim, Min-Jin (Nakdonggang National Institute of Biological Resources) ;
  • Kim, Seoyeon (Department of Chemistry and Cosmetics, Jeju National University) ;
  • Hyun, Kwang Hee (Helios) ;
  • Kim, Duk Soo (Department of Chemistry and Cosmetics, Jeju National University) ;
  • Kim, Seung-Young (Department of BT Convergent Pharmaceutical Engineering, Sunmoon University) ;
  • Hyun, Chang-Gu (Department of Chemistry and Cosmetics, Jeju National University)
  • 김민진 (국립낙동강생물자원관) ;
  • 김서연 (제주대학교 화학.코스메틱스학과) ;
  • 현광희 (헬리오스) ;
  • 김덕수 (제주대학교 화학.코스메틱스학과) ;
  • 김승영 (선문대학교 BT융합제약공학과) ;
  • 현창구 (제주대학교 화학.코스메틱스학과)
  • Received : 2017.07.21
  • Accepted : 2017.08.16
  • Published : 2017.09.30
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Abstract

In this study, we investigated the effect of Rumex axetosella, Sonchus oleraceus and Euphoibia jolkini extracts on tyrosinase activity and melanin production as natural products of whitening functional cosmetics. To measure the melanin production, 50, 100, $200{\mu}g/mL$ of Rumex axetosella, Sonchus oleraceus and Euphoibia jolkini extracts were treated on ${\alpha}-MSH$ treated B16F10 melanoma cells, respectively. Melanin contents in ${\alpha}-MSH$ treated B16F10 melanoma cells were decreased by 41.5, 51.11, and 61% in $200{\mu}g/mL$ treatment compared to none treatment, respectively. In addition, the intracellular tyrosinase activity was decreased after treatments with all extracts. Furthermore, $100{\mu}g/mL$ of Euphoibia jolkini extract was decreased 81.5% of melanin production in B16F10 melanoma cells. When the three extracts were compared, Euphoibia jolkini extract was considered to be the most functional material for whitening effect.

Keywords

Acknowledgement

Supported by : 한국연구재단

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