한국방사선학회논문지 (Journal of the Korean Society of Radiology)

  • 제11권4호
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  • Pages.205-212
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  • 2017
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  • 1976-0620(pISSN)
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  • 2384-0633(eISSN)
한국방사선학회 (The Korean Society of Radiology)
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초음파영상을 이용한 간탄력도 검사의 유용성

The Usefulness of Liver Fibroscan Test Using Ultrasound Image

  • 안현 (인제대학교 부산백병원 영상의학과) ;
  • 이진수 (인제대학교 해운대백병원 영상의학과) ;
  • 임인철 (동의대학교 방사선학과) ;
  • 양성희 (일신기독병원 영상의학과)
  • An, Hyun (Department of Radiology, Inje University Busan Paik Hospital) ;
  • Lee, Jin-Soo (Department of Radiology, Inje University Haeundae Paik Hospital) ;
  • Im, In-Chul (Department of Radiological Science, Dongeui University) ;
  • Yang, Sung-Hee (Department of Radiology, Ilsin Christian Hospital)
  • 투고 : 2017.06.15
  • 심사 : 2017.08.31
  • 발행 : 2017.08.31
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초록

만성간질환(Chronic diffuse hepatopathy)의 진단은 간경화, 간부전, 간암으로 인한 사망률과 유병율을 감소시키는 중요한 임상과제 중 하나이다. 이에 본 연구에서는 초음파진단 영상을 바탕으로 간탄력도검사(Fibroscan)를 통해 지방간, 만성간질환을 예측할 수 있는 기준을 알아보고자 하였다. 280명의 환자를 대상으로 혈청학적 검사, 간탄력도 검사 측정값(kPa)을 분석하였으며 ROC 곡선분석을 이용하여 지방간 및 만성간질환을 예측을 위한 간탄력도 측정값의 cut-off value를 결정하였다. 혈청학적 검사에서 Bililubin, PT(prothrombin time)은 질병예측에 관련성이 없었으며(p=0.243, p=0.115), 혈당과 중성지방수치는 지방간에서 의미 있는 차이를 보이며 높게 나타났다(p<0.05). 간탄력도 측정값은 정상 대조군, 지방간, 만성간질환 순으로 높게 측정되었으며 만성간질환 예측을 위한 cut-off value는 10.3 kPa(AUC 0.98, Sensitivity 94.94%, Specificity 94.93%)로 결정하였다. 따라서 정량적인 평가로 만성간질환 환자의 진단에 일차적인 도구로 활용될 것으로 사료된다.

Chronic diffuse hepatopathy is one of the important clinical tasks to reduce mortality and morbidity due to liver cirrhosis, liver failure, and liver cancer. The purpose of this study was to evaluate the criteria for predicting liver and chronic liver disease using Fibroscan based on ultrasound diagnosis. Serum and liver stiffness measurement(kPa) were analyzed in 280 patients and cut-off values of liver stiffness measurement for predicting fatty liver and chronic diffuse hepatopathy were determined using ROC curve analysis. Bilirubin and PT(prothrombin time) were not related to disease prediction(p=0.243, p=0.115). Serum glucose and triglyceride levels were significantly higher in the liver (p<0.05). The cut-off value for predicting chronic diffuse hepatopathy was determined as 10.3 kPa(AUC 0.98, sensitivity 94.94%, specificity 94.93%) in the order of control group, fatty liver and chronic diffuse hepatopathy. Therefore, it will be used as a primary tool for the diagnosis of chronic liver disease patients with quantitative evaluation.

키워드

참고문헌

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피인용 문헌

  1. 초음파 소견에 따른 간 탄성도 분석 vol.15, pp.6, 2017, https://doi.org/10.7742/jksr.2021.15.6.883