The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Anti-Diabetic and Anti-Inflammatory Effects of Purple Corn Extract in High-Fat Diet Induced Obesity Mice

고지방식이 비만 유도 마우스에서 자색옥수수 추출물의 항당뇨 및 항염증 효과

  • Joung, Hyunchae (School of Life Science, Handong Global University) ;
  • Kim, Chai-hee (School of Life Science, Handong Global University) ;
  • Lee, Yejoo (School of Life Science, Handong Global University) ;
  • Kim, Soon-kwon (School of Life Science, Handong Global University) ;
  • Do, Myoung-Sool (School of Life Science, Handong Global University)
  • 정현채 (한동대학교 생명과학부) ;
  • 김채희 (한동대학교 생명과학부) ;
  • 이예주 (한동대학교 생명과학부) ;
  • 김순권 (한동대학교 생명과학부) ;
  • 도명술 (한동대학교 생명과학부)
  • Received : 2017.05.29
  • Accepted : 2017.06.23
  • Published : 2017.08.31
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Abstract

Metabolic syndrome, including obesity, glucose intolerance and elevated blood pressure, is related to type 2 diabetes and cardiovascular disease. Previous studies have reported the anti-oxidative, anti-inflammatory and anti-diabetic effects of purple corn extract. We investigated the efficacy of purple corn extract (PC) against high-fat diet (HFD)-induced obesity and glucose intolerance, and examined the underlying mechanisms by analyzing expression of proteins and genes involved in glucose regulation and macrophage infiltration. C57BL/6 mice were fed with normal chow diet (ND), or HFD treated with distilled water (DW, control) or PC, for 10 weeks. Although body weights were similar in the HFD-fed groups, we observed a decrease in the liver and epididymal adipose tissue (EAT) weights, and enhanced glucose tolerance test (GTT) results in the PC group, as compared with DW group. Liver showed increased Akt phosphorylation in the PC-treated mice; however, no changes were observed in the EAT, for all groups. In PC-treated mice, decreased macrophage infiltration was seen in the EAT, with a reduced expression of macrophage marker genes. Finally, proinflammatory cytokine gene expressions were decreased by PC in the EAT, and a modest trend for downregulation was observed in the liver. Hence, we conclude that PC may decrease glucose intolerance by increasing the phosphorylation of Akt and reducing the macrophage infiltration into the EAT.

Keywords

References

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