Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants

  • Say, Birgul (Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital) ;
  • Uras, Nurdan (Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital) ;
  • Sahin, Suzan (Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital) ;
  • Degirmencioglu, Halil (Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital) ;
  • Oguz, Serife Suna (Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital) ;
  • Canpolat, Fuat Emre (Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital)
  • 투고 : 2016.04.15
  • 심사 : 2016.12.21
  • 발행 : 2017.08.15
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초록

Purpose: Vitamin D plays a key role in immune function. Vitamin D deficiency may play a role in the pathogenesis of infections, and low levels of circulating vitamin D are strongly associated with infectious diseases. In this study, we aimed to evaluate the effects of low vitamin D levels in cord blood on neonatal sepsis in preterm infants. Methods: One hundred seventeen premature infants with gestational age of <37 weeks were enrolled. In the present study, severe vitamin D deficiency (group 1) was defined as a 25-hydroxyvitamin D (25(OH)D) concentration <5 ng/mL; vitamin D insufficiency (group 2), 25(OH)D concentration ${\geq}5ng/mL$ and <15 ng/mL; and vitamin D sufficiency (group 3), 25(OH)D concentration ${\geq}15ng/mL$. Results: Sixty-three percent of the infants had deficient levels of cord blood vitamin D (group 1), 24% had insufficient levels (group 2), and 13% were found to have sufficient levels (group 3). The rate of neonatal sepsis was higher in group 2 than in groups 1 and 3. Conclusion: There was no significant relationship between the cord blood vitamin D levels and the risk of neonatal sepsis in premature infants.

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참고문헌

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  2. Vitamin D and associated perinatal-neonatal outcomes among extremely low-birth-weight infants vol.38, pp.10, 2017, https://doi.org/10.1038/s41372-018-0203-y
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  7. Vitamin D in Acute and Critically Sick Children with a Subgroup of Sepsis and Mortality: A Meta-Analysis vol.73, pp.7, 2021, https://doi.org/10.1080/01635581.2020.1784964
  8. The Role of Low 25-Hydroxyvitamin D Levels in Preterm Infants with Late-Onset Sepsis vol.40, pp.6, 2021, https://doi.org/10.1080/15513815.2020.1725941