Clinical and Experimental Reproductive Medicine

  • 제44권2호
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  • Pages.105-110
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  • 2017
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  • 2233-8233(pISSN)
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  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
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Mixed double-embryo transfer: A promising approach for patients with repeated implantation failure

  • 투고 : 2017.03.17
  • 심사 : 2017.05.17
  • 발행 : 2017.06.30
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초록

Objective: The purpose of this study was to evaluate the efficacy of frozen mixed double-embryo transfer (MDET; the simultaneous transfer of day 3 and day 5 embryos) in comparison with frozen blastocyst double-embryo transfer (BDET; transfer of two day 5 blastocysts) in patients with repeated implantation failure (RIF). Methods: A total of 104 women with RIF who underwent frozen MDET (n = 48) or BDET (n = 56) with excellent-quality embryos were included in this retrospective analysis. All frozen embryo transfers were performed in natural cycles. The main outcome measures were the implantation rate, clinical pregnancy rate, multiple pregnancy rate, and miscarriage rate. These measures were compared between the patients who underwent MDET or BDET using the chi-square test or the Fisher exact test, as appropriate. Results: The implantation and clinical pregnancy rates were significantly higher in patients who underwent MDET than in those who underwent BDET (60.4% vs. 39.3%, p=0.03 and 52.1% vs. 30.4%, p=0.05, respectively). A significantly lower miscarriage rate was observed in the MDET group (6.9% vs. 10.7%, p=0.05). In addition, the multiple pregnancy rate was slightly, but not significantly, higher in the MDET group (27.1% vs. 25.0%). Conclusion: MDET was found to be significantly superior to double blastocyst transfer. It could be regarded as an appropriate approach to improve in vitro fertilization success rates in RIF patients.

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참고문헌

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피인용 문헌

  1. Successful Pregnancy following Mixed Double Embryo Transfer in a Patient with Variable Window of Implantation vol.2018, pp.None, 2017, https://doi.org/10.1155/2018/1687583
  2. The effects of autologous platelet-rich plasma in repeated implantation failure: a randomized controlled trial vol.23, pp.3, 2017, https://doi.org/10.1080/14647273.2019.1569268
  3. Effect of platelet-rich plasma on pregnancy outcomes in infertile women with recurrent implantation failure: a randomized controlled trial vol.37, pp.2, 2017, https://doi.org/10.1080/09513590.2020.1756247
  4. Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review vol.19, pp.1, 2017, https://doi.org/10.1186/s12958-021-00824-y