한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제21권2호
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  • Pages.121-130
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  • 2017
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  • 2465-9525(pISSN)
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  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
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Disturbing Effects of Chronic Low-dose 4-Nonylphenol exposing on Gonadal Weight and Reproductive Outcome over One-generation

  • Cha, Sunyeong (Division of Developmental Biology and Physiology, School of Biological Sciences and Chemistry, Sungshin University) ;
  • Baek, Jeong Won (Division of Developmental Biology and Physiology, School of Biological Sciences and Chemistry, Sungshin University) ;
  • Ji, Hye Jin (Division of Developmental Biology and Physiology, School of Biological Sciences and Chemistry, Sungshin University) ;
  • Choi, Jun Hee (Division of Developmental Biology and Physiology, School of Biological Sciences and Chemistry, Sungshin University) ;
  • Kim, Chaelim (Division of Developmental Biology and Physiology, School of Biological Sciences and Chemistry, Sungshin University) ;
  • Lee, Min Young (Division of Developmental Biology and Physiology, School of Biological Sciences and Chemistry, Sungshin University) ;
  • Hwang, Yeon Jeong (Division of Developmental Biology and Physiology, School of Biological Sciences and Chemistry, Sungshin University) ;
  • Yang, Eunhyeok (Division of Developmental Biology and Physiology, School of Biological Sciences and Chemistry, Sungshin University) ;
  • Lee, Sung-Ho (Department of Lifesicence, Sangmyung University) ;
  • Jung, Hyo-il (School of Mechanical Engineering, Yonsei University) ;
  • Cheon, Yong-Pil (Division of Developmental Biology and Physiology, School of Biological Sciences and Chemistry, Sungshin University)
  • 투고 : 2017.04.03
  • 심사 : 2017.04.07
  • 발행 : 2017.06.30
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초록

4-Nonylphenol (NP) is a surfactant that is a well-known and widespread estrogenic endocrine disrupting chemical (EDC). Although it has been known that the affinity of NP to ERs is low, it has been suggested that low-dose NP has toxicity. In the present study, the endocrine disrupting effects on reproduction, and the weight of gonads, epididymis, and uterus were evaluated with the chronic lower-dose NP exposing. This study was designed by following the OECD test guideline 443 and subjected to a complete necropsy. In male, NP had an effect on the weight of the testis and epididymis in both $F_0$ and $F_1$. In females, NP decreased the weight of ovary and uterus in $F_0$ but not in pre-pubertal $F_1$ pubs. Fertility of male and female in $F_0$ or $F_1$ was no related with NP administration. The number of caudal-epididymal sperm by body weight (BW) was not different between groups in both $F_0$ and $F_1$. Besides, the difference of the sperm number between generations was not detected. The number of ovulated oocytes was similar between groups in $F_0$, but significantly decreased in NP 50 group of $F_1$. The litter size and sex ratios of offspring in $F_1$ and $F_2$ were not different. The accumulated mating rate and gestation period were not affected by the NP administration. Those results shows that chronic lower-dose NP administration has an effect of endocrine disruptor on the weight of gonads and epididymis of $F_0$ and $F_1$ but not in reproduction. Based on the results, it is suggested that chronic lower-dose NP exposing causes endocrine disruption in the weight of gonad and epididymis but not in the reproductive ability of next generations.

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참고문헌

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