The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Dyslipidemic Effect of Pravastatin and Herbal Medicine in Rats

고지방식이유도 실험용 Rat에서 Statin 및 한약 2종(후박, 하수오) 투여에 따른 혈중 지질, 조직 변화 비교 연구

  • Park, Sung-woon (East-West Medicine Department, Kyung Hee University Korean Medicine Hospital) ;
  • Seo, Yoon-jeong (East-West Medicine Department, Kyung Hee University Korean Medicine Hospital) ;
  • Choi, Hyun-jeong (East-West Medicine Department, Kyung Hee University Korean Medicine Hospital) ;
  • Lew, Jae-hwan (East-West Medicine Department, Kyung Hee University Korean Medicine Hospital)
  • 박성운 (경희대학교 한방병원 동서협진실) ;
  • 서윤정 (경희대학교 한방병원 동서협진실) ;
  • 최현정 (경희대학교 한방병원 동서협진실) ;
  • 유재환 (경희대학교 한방병원 동서협진실)
  • Received : 2017.05.25
  • Accepted : 2017.06.27
  • Published : 2017.06.30
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Abstract

Objective: The goal of this preclinical study was to compare the dyslipidemic effect of pravastatin with that of herbal medicine in rats. Methods: In total, 40 rats were divided into 4 groups: Normal (10 rats), Control (10 rats), Statin alone (10 rats), and the MO-PM-S group (10 rats), which was given the powder of the cortex of Magnolia officinalis Rehd. et Wils., the root of Polygonum multiflorum Thunb, and pravastatin. The Control group, the Statin alone group, and the MO-PM-S group were all given a high-fat (45%) diet that made them obese. After 2 weeks of drug administration, the dyslipidemic effect of pravastatin was compared with that of herbal medicine in rats by analyzing the lipid profiles, measuring the body weights, and taking biopsies (liver, aorta). Results: The herbal medicine and the statin complex group got a much lower TG level and a slightly higher HDL-cholesterol level than the other groups. However, it got a higher total cholesterol and LDL-cholesterol level than the other groups. In biopsies, 30% of the Statin alone group and 10% of the MO-PM-S group showed mild histopathologic findings in the liver. Conclusion: The cortex of the Magnolia officinalis Rehd. et Wils. and the root of Polygonum multiflorum Thunb have dyslipidemic effects from the perspective of a TG level and HDL-cholesterol. However, the herbal mixture has a raising effect on both the LDL-cholesterol and the total cholesterol levels. Therefore, we cannot conclude that the herbal mixture helps to prevent dyslipidemia. In liver biopsies, the group administered with both the herbal mixture and the statin showed less histopathologic findings than the group administered with statin alone. This means that the herbal mixture helps to prevent fatty degeneration of the liver.

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