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건강검진에서 지방간 진단의 상복부초음파검사와 간 Hounsfield Units 측정값과의 정확성 분석

Fatty Liver Diagnostics from Medical Examination to Analyze the Accuracy Between the Abdominal Ultrasonography and Liver Hounsfield Units

  • 오왕균 (충청북도 청주의료원 영상의학과) ;
  • 김상현 (신한대학교 방사선학과)
  • Oh, Wang-Kyun (Department of Radiology, Cheongju Medical Center) ;
  • Kim, Sang-Hyun (Department of Radiological Science, Shinhan University)
  • 투고 : 2016.06.04
  • 심사 : 2016.06.19
  • 발행 : 2017.06.30

초록

상복부초음파검사에서 간실질의 에코 음영증가와 불명확한 혈관경계 등으로 지방간을 진단하는데, 여러 연구들에 의하면 지방간 진단에 84~95%의 특이도와 60~90%의 민감도를 가지나 결과가 검사자에 의존적이어서 차이가 있을 수 있고 지방의 침윤 상태의 정량적인 측정이 불가능하다. 건강검진의 상복부초음파검사와 흉부 전산화단층촬영(computed tomography; CT) 검사를 같은 날에 시행한 수검자중 초음파검사에서 지방간을 진단 받은 환자의 흉부 전산화단층촬영 영상에서 간(Liver) Hounsfield Units(HU)를 측정하여 지방간 진단의 정확성을 연관분석 하고자 하였다. 연구대상 수검자 720명 중 가정의학과 전문의에게 검사를 받고 지방간 판정을 받은 자는 448명으로 62.2%였다. 지방간 판정자의 CT영상에서 간 HU를 측정한 결과 40 HU 이하의 측정값은 720명 중 175명으로 24.3%이며, 초음파에서 진단 받은 448명에 175명 중 173명이 포함되어 98.9%가 일치하였다. 이는 지방간을 초음파로 진단 시 검사자의 주관적 경험과 능력이 병변을 진단하는데 크게 영향을 미친 것으로 생각되며 검진 CT검사에서 간 HU를 측정하여 40 HU 이하는 영상저장을 통하여 지방간 진단 시 참고자료로 활용될 수 있을 것으로 사료된다.

In abdominal Ultrasonography, the fatty liver is diagnosed through hepatic parenchymal echo increased parenchymal density and unclear blood vessel boundary, and according to many studies, abdominal Ultrasonography has 60~90% of sensitivity and 84~95% of specificity in diagnosis of fatty liver, but the result of Ultrasonography is dependent on operators, so there can be difference among operators, and quantitative measurement of fatty infiltration is impossible. Among examinees who same day received abdominal Ultrasonography and chest computed tomography (CT), patients who were diagnosed with a fatty liver in the Ultrasonography were measured with liver Hounsfield Units (HU) of chest CT imaging to analyze the accuracy of the fatty liver diagnosis. Among 720 subject examinees, those who were diagnosed with a fatty liver through abdominal Ultrasonography by family physicians were 448, which is 62.2%. The result of Liver HU measurement in the chest CT imaging of those who were diagnosed with a fatty liver showed that 175 out of 720 had the measured value of less than 40 HU, which is 24.3%, and 173 were included to the 175 among 448 who were diagnosed through Ultrasonography, so 98.9% corresponded. This indicates that the operators' subjective ability has a great impact on diagnosis of lesion in Ultrasonography diagnosis of a fatty liver, and that in check up chest CT, under 40 HU in the measurement of Liver HU can be used for reference materials in diagnosis of a fatty liver.

키워드

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