생약학회지 (Korean Journal of Pharmacognosy)

  • 제48권2호
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  • Pages.108-112
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  • 2017
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

목천료의 RAW264.7과 BV2 세포주에서의 일산화질소 생성 억제효과 트리테르펜

Triterpenes with Inhibitory Effects of Nitric Oxide Production from the Fruit Galls of Actinidia polygama on LPS-Induced RAW264.7 and BV2 Cells

  • 리소군 (원광대학교 약학대학 약품연구소) ;
  • 김관우 (원광대학교 약학대학 약품연구소) ;
  • 고원민 (원광대학교 약학대학 약품연구소) ;
  • 김동철 (원광대학교 약학대학 약품연구소) ;
  • 윤치수 (원광대학교 약학대학 약품연구소) ;
  • 유향전 (후난중의약대학) ;
  • 오현철 (원광대학교 약학대학 약품연구소) ;
  • 김윤철 (원광대학교 약학대학 약품연구소)
  • Li, Xiao Jun (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Kwan-Woo (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Ko, Wonmin (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Dong-Cheol (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Yoon, Chi-Su (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Liu, Xiang Qian (School of Pharmacy, Hunan University of Chinese Medicine) ;
  • Oh, Hyuncheol (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Youn-Chul (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University)
  • 투고 : 2016.06.09
  • 심사 : 2017.03.03
  • 발행 : 2017.06.30
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초록

To isolate and identify the constituents of the fruit galls of Actinidium polygama as well as evaluate the anti-inflammatory effects of the isolated compounds, a total of five triterpenes were isolated including $2{\alpha},3{\alpha},24$-trihydroxy-12-ursene-23-al-28-oic acid (1), corosolic acid (2), $2{\alpha},3{\alpha},24$-trihydroxyurs-12,20(30)-dien-28-oic acid (3), $2{\alpha},3{\alpha},24$-trihydroxyolean-12-en-28-oic acid (4), and $2{\alpha},3{\alpha},24$-trihydroxyurs-12-en-28-oic acid (pygenic acid B) (5). Compounds 1, 3, and 4 were isolated from the fruit galls of A. polygama for the first time. Compound 3 decreased NO production in LPS-stimulated RAW264.7 macrophages and mouse microglia BV2 cells in a concentration-dependent manner.

키워드

참고문헌

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