International Journal of Industrial Entomology and Biomaterials

Korean Society of Sericultural Science (한국잠사학회)
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Comparative study on bone regeneration between silk mat incorporated 4-hexylresorcinol and collagen membrane

  • Seok, Hyun (Department of Oral and Maxillofacial Surgery, Chungbuk National University Hospital) ;
  • Jo, You-Young (Sericultural and Apicultural Materials Division, National Academy of Agricultural Science) ;
  • Kweon, HaeYong (Sericultural and Apicultural Materials Division, National Academy of Agricultural Science) ;
  • Baek, Dong-Heon (School of Oral Microbiology, Dankook University) ;
  • Kim, Seong-Gon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University)
  • Received : 2017.05.30
  • Accepted : 2017.06.20
  • Published : 2017.06.30
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Abstract

The purpose of this study was (1) to demonstrate the anti-microbial properties of 4-hexylresorcinol (4HR) loaded silk mat and (2) comparison of bone formation between 4HR incorporated silk mat and collagen membrane. Anti-microbial properties of 4HR incorporated silk mat was done after sterilization of silk mat (autoclaving and ethylene oxide gas). For the evaluation of bone formation, bilateral bony defects (size: 8 mm) were prepared in the parietal bone of the rabbits (n=10). 4HR incorporated silk mat (size: $10{\times}10mm$) was applied on the right defect. For the comparative purpose, the same size of commercial collagen membrane was applied on the left defect. The anti-microbial properties of 4HR incorporated silk mat were maintained after sterilization process. When compared bone mineral density and bone volume, there was no statistically significant difference between groups at 4 weeks and 8 weeks after operation (p>0.05). In conclusion, 4HR incorporated silk mat could be autoclaved without concern of anti-microbial properties loss. In addition, 4HR incorporated silk mat showed similar bone regeneration to collagen membrane. Therefore, 4HR incorporated silk mat might be considered for the application of open membrane technique.

Keywords

References

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