Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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The Usefulness of Serum Lipid Concentration as a Predictor of Convulsion in Patients with Glufosinate Ammonium Poisoning

글루포시네이트 암모늄 중독환자에서 경련 예측인자로서의 혈중 지질 농도의 유용성

  • Lee, Hyun Do (Department of Emergency medicine, College of Medicine, Chosun University) ;
  • Sun, Kyung Hoon (Department of Emergency medicine, College of Medicine, Chosun University) ;
  • Kim, Seong Jung (Department of Emergency medicine, College of Medicine, Chosun University)
  • 이현도 (조선대학교 의과대학 응급의학교실) ;
  • 선경훈 (조선대학교 의과대학 응급의학교실) ;
  • 김성중 (조선대학교 의과대학 응급의학교실)
  • Received : 2017.04.07
  • Accepted : 2017.05.29
  • Published : 2017.06.30
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Abstract

Purpose: Glufosinate ammonium (GA; phosphinothricin) can induce neurological complications such as altered mental status, amnesia, and convulsions. This study was conducted to evaluate whether blood lipid profiles can help predict convulsions in patients with GA poisoning. Methods: This study was a retrospective review of data acquired at a tertiary academic university hospital from March 2014 to July 2016. Independent t-test, Mann-Whitney test and Analysis of covariance (ANCOVA) of demographic and laboratory findings of 50 patients with GA poisoning were performed to identify correlations of general characteristics and laboratory findings, including blood lipid profiles of GA-poisoned patients between with and without convulsions. Results: Convulsion as a GA complication showed a significant association with poison volume, age, white blood cell count, and creatine phosphokinase (CK), albumin, lactate dehydrogenase (LDH), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) content in blood according to an independent t-test and Mann-Whitney test. However, ANCOVA demonstrated significant association with LDL and triglyceride. Conclusion: Blood lipid profiles, especially serum LDL and triglyceride, were useful in predicting convulsions in patients with GA poisoning.

Keywords

References

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