Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Hypoalbuminemia as a Predictor of 30-day Mortality in Patients with Acute Organophosphate Insecticide Poisoning

유기인계 살충제 중독환자에서 30일 사망률에 대한 예후 예측인자로서의 저알부민혈증의 유용성

  • Kim, So Yeon (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Lee, Ryun Kyung (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Kim, Tae hu (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Kim, Dong Hoon (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Kim, Taeyun (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Lee, Soo Hoon (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Jeong, Jin Hee (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Lee, Sang Bong (Department of Emergency Medicine, Gyeongsang National University School of Medicine) ;
  • Kang, Changwoo (Department of Emergency Medicine, Gyeongsang National University School of Medicine)
  • 김소연 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 이륜경 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 김태후 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 김동훈 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 김태윤 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 이수훈 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 정진희 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 이상봉 (경상대학교 의과대학/의학전문대학원 응급의학교실) ;
  • 강창우 (경상대학교 의과대학/의학전문대학원 응급의학교실)
  • Received : 2017.05.08
  • Accepted : 2017.06.19
  • Published : 2017.06.30
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Abstract

Purpose: The association of hypoalbuminemia with 30-day in-hospital mortality in patients with organophosphate insecticide poisoning (OPI) was studied. Methods: This retrospective cohort study was conducted between January 2006 and November 2013 in the emergency department (ED) after OPI poisoning. A Kaplan-Meier 30-day survival curve and the log-rank test were used to analyze patients stratified according to serum albumin levels on ED admission (hypoalbuminemia or normo-albuminemia). Independent risk factors including hypoalbuminemia for 30-day mortality were determined by multivariate Cox regression analysis. Results: A total of 135 patients were included. Eighty-eight (65%) patients were male and the mean age was $57.3{\pm}17.0$ years. Serum albumin, mean arterial pressure, and Glasgow coma scale score were significantly higher in the survival group than the non-survival group. APACHE II score was significantly lower in the non-survival group than the survival group. The mortality of the hypoalbuminemia group (serum albumin <3.5 g/dl) was 68.8%, while that of the normo-albuminemia group (serum albumin ${\geq}3.5g/dl$) was 15.1%. The area under the ROC curve of the serum albumin level was 0.786 (95% CI, 0.690-0.881) and the APACHE II score was 0.840 (95% CI, 0.770-0.910). Conclusion: Hypoalbuminemia is associated with 30-day mortality in patients with OPI poisoning.

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References

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