The Effects of Implementation of Ventilator-Associated Pneumonia Prevention Bundles

인공호흡기 관련 폐렴 예방 번들 적용의 효과

  • Kim, Sea Joung (Inje University Haeundae Paik Hospital) ;
  • Lee, Yun Mi (Department of Nursing, Institute of Health Science, Inje University) ;
  • Cho, Jeonghyun (Department of Nursing, Institute of Health Science, Inje University)
  • 김세정 (인제대학교 해운대백병원 간호과) ;
  • 이윤미 (인제대학교 간호학과, 건강과학연구소) ;
  • 조정현 (인제대학교 간호학과, 건강과학연구소)
  • Received : 2017.05.31
  • Accepted : 2017.06.25
  • Published : 2017.06.30

Abstract

Purpose: The purpose of this study was to evaluate the effectiveness of a ventilator-associated pneumonia (VAP) bundle. Methods: This was a retrospective study that was carried out between June 2010 and October 2015. In this study, 3,224 intubated patients were included. The VAP bundle which was applied to Group 1 patients (n=470) included head-of-bed elevation to 30 degrees, cuff pressure monitorization, prophylaxis of peptic ulcer, and prophylaxis of deep vein thrombosis. The VAP bundle for Group 2 patients (n=1,914) included all the elements of the VAP bundle for Group 1 patients and one additional element which was oral care with 0.12% chlorhexidine. The VAP bundle for Group 3 patients (n=870) added sedative interruption and assessment of readiness to extubate to the VAP bundle for Group 2. Results: The numbers and incidences of VAP were significantly different among the three groups. Moreover, there were significant differences among groups in ICU length of stay and mortality. Conclusion: Three different VAP prevention bundles made different effects in patient outcomes.

Keywords

References

  1. American Thoracic Society (2005). Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneu-monia. American Journal of Respiratory Critical Care Medicine, 171(4), 388-416. https://doi.org/10.1164/rccm.200405-644ST
  2. Ban, K. O. (2009). The development and effectiveness of a program to prevent ventilator associated pneu-monia in the ICU. Korean Journal of Adult Nursing, 21(2), 155-166.
  3. Berenholtz, S. M., Pham, J. C., Thompson, D. A., Needham, D. M., Lubomski, L. H., Hyzy, R. C., ... Pronovost, P. J. (2011). Collaborative cohort study of an intervention to reduce ventilator-associated pneumonia in the intensive care unit. Infection Control and Hospital Epidemiology, 32(4), 305-314. https://doi.org/10.1086/658938
  4. Bouadma, L., Wolff, M., & Lucet, J. C. (2012). Ventilator-associated pneumonia and its prevention. Current Opinion in Infectious Diseases, 25(4), 395-404. https://doi.org/10.1097/QCO.0b013e328355a835
  5. Burger, C. D., & Resar, R. K. (2006). "Ventilator bundle" approach to prevention of ventilator-associated pneumonia. Mayo Clinic Procceedings, 81(6), 849-850. https://doi.org/10.4065/81.6.849
  6. Eom, J. S., Lee, M. S., Chun, H. K., Choi, H. J., Jung, S. Y., Kim, Y. S., ... Lee, J. S. (2014). The impact of a ventilator bundle on preventing ventilator-associated pneumonia: a multicenter study. American Journal of Infection Control, 42(1), 34-37. https://doi.org/10.1016/j.ajic.2013.06.023
  7. Girard, T. D., Kress, J. P., Fuchs, B. D. Thomason, J. W., Schweickert, W. D., Pun, B. T., ... Ely, E. W. (2008). Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled Trial): a randomized controlled trial. Lancet, 371(9607), 126134.
  8. Khan, R., Al-Dorzi, H. M., Al-Attas, K., Ahmed, F. W., Marini, A. M., Mundekkadan, S., ... Arabi, Y. M. (2016). The impact of implementing multifaceted interventions on the prevention of ventilator-associated pneumonia. American Journal of Infection Control, 44(3), 320-326. https://doi.org/10.1016/j.ajic.2015.09.025
  9. Klompas, M., Li, L., Kleinman, K., Szumita, P. M., & Massaro, A. F. (2016). Associations between ventilator bundle components and outcomes. JAMA Internal Medicine, 176(9), 1277-1283. https://doi.org/10.1001/jamainternmed.2016.2427
  10. Kollef, M. H., Hamilton, C. W., & Ernst, F. R. (2012). Economic impact of ventilator-associated pneumonia in a large matched cohort. Infection Control and Hospital Epidemiology, 33(3), 250-256. https://doi.org/10.1086/664049
  11. Kwak, Y. K., Choi, J. Y., Yoo, H. M., Lee, S. O., Kim, H. B., Han, S. H., ... Lee, K. (2016). Korean national healthcare-associated infection surveillance system, intensive care unit module report: summary of data from July 2014 through June 2015. Korean Journal of Healthcare-Associated Infection Control and Prevention, 21(2), 37-49. https://doi.org/10.14192/kjhaicp.2016.21.2.37
  12. Lawrence, P. & Fulbrook, P. (2011). The ventilator care bundle and its impact on ventilator-associated pneumonia: a review of the evidence. Nursing in Critical Care, 16(5), 222-34 https://doi.org/10.1111/j.1478-5153.2010.00430.x
  13. Marra, A. R., Cal, R. G., Silva, C. V., Caserta, R. A., Paes, A. T., Moura, D. F., ... Durao, M. S. (2009). Successful prevention of ventilator-associated pneu-monia in an intensive care setting. American Journal of Infection Control, 37(8), 619-625. https://doi.org/10.1016/j.ajic.2009.03.009
  14. Melsen, W. G., Rovers, M. M., Groenwold, R. H., Bergmans, D. C., Camus, C., Bauer, T. T., ... Bonten, M. J. (2013). Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies. The Lancet. Infectious Diseases, 13(8), 665-671. https://doi.org/10.1016/S1473-3099(13)70081-1
  15. Munro, N., & Ruggiero, M. (2014). Ventilator-associated pneumonia bundle: reconstruction for best care. AACN Advanced Critical Care, 25(2), 163-175. https://doi.org/10.1097/NCI.0000000000000019
  16. Muscedere, J., Dodek, P., Keenan, S., Fowler, R., Cook, D., & Heyland, D. (2008). Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia prevention. Journal of Critical Care, 23(1), 126-137. https://doi.org/10.1016/j.jcrc.2007.11.014
  17. Nolan, T., & Berwick, D.M. (2006). All-or-none measurement raises the bar on performance. Journal of the American Medical Association, 295(10), 1168- 1170. https://doi.org/10.1001/jama.295.10.1168
  18. Rello, J., Afonso, E., Lisboa, T., Ricart, M., Balsera, B., Rovira, A., & Valles, E. D. (2013). A care bundle approach for prevention of ventilator-associated pneumonia. Clinical Microbiology and Infection, 19(4), 363-369. https://doi.org/10.1111/j.1469-0691.2012.03808.x
  19. Rello, J., Lode, H., Cornaglia, G., &Masterton, R. (2010). A European care bundle for prevention of ventilator-associated pneumonia. Intensive Care Medicine, 36(5), 773-80. https://doi.org/10.1007/s00134-010-1841-5
  20. Resar, R., Pronovost, P., Haraden, C., Simmonds, T., Rainey, T., & Nolan, T. (2005). Using a bundle approach to improve ventilator care processes and reduce ventilator-associated pneumonia. Joint Commission Journal of Quality and Patient Safety, 31(5), 243-248. https://doi.org/10.1016/S1553-7250(05)31031-2
  21. Restrepo, M. I., Anzueto, A., Arroliga, A. C. Afessa, B., Atkinson, M. J., Ho, N. J., ... Kollef, M. H. (2010). Economic burden of ventilator-associated pneumonia based on total resource utilization. Infection Control and Hospital Epidemiology, 31(5), 509-515. https://doi.org/10.1086/651669
  22. Richards, M. J., Edwards, J. R., Culver, D. H., & Gaynes, R. P. (2000). Nosocomial infections in combined medical-surgical intensive care units in the United States. Infection Control and Hospital Epidemiology, 21(8), 510-515. https://doi.org/10.1086/501795
  23. Rosenthal, V. D., Rodrigues, C., Alvarez-Moreno, C., Madani, N., Mitrev, Z., Ye, G., ... Fernandez-Hidalgo, R. (2012). Effectiveness of a multidimensional approach for prevention of ventilator-associated pneumonia in adult intensive care units from 14 developing countries of four continents: findings of the International Nosocomial Infection Control Consortium. Critical Care Medicine, 40(12), 3121-3128. https://doi.org/10.1097/CCM.0b013e3182657916
  24. Safdar, N., Dezfulian, C., Collard, H. R., & Saint, S. (2005). Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Critical Care Medicine, 33(10), 2184-2193. https://doi.org/10.1097/01.CCM.0000181731.53912.D9
  25. Yongquist, P., Carroll, M., Farber, M, Macy, D., Madrid, P., Ronning, J., & Susag, A. (2007). Implementing a ventilator bundle in a community hospital. The Joint Commission on Quality and Patient Safety, 33(4), 219-225. https://doi.org/10.1016/S1553-7250(07)33026-2
  26. Yoo, S. Y. (2015). Impact of the ventilator-associated pneumonia bundle in a medical intensive care unit (Unpublished master's thesis). Ulsan University, Ulsan, Korea.
  27. Zhang, Z., Hou ,Y., Zhang, J.,Wang, B., Zhang, J., Yang, A., ... Tian, J. (2017). Comparison of the effect of oral care with four different antiseptics to prevent ventilator-associated pneumonia in adults: protocol for a network meta-analysis. Systematic Reviews, 6(1), 103. https://doi.org/10.1186/s13643-017-0496-5
  28. Zimmerman,J. E., Kramer, A. A.,McNair, D. S.,Malila, F. M., & Shaffer, V. L.(2006). Intensive care unit length of stay: benchmarking based on acute physiology and chronic health evaluation (APACHE) IV. Critical Care Medicine, 34(10), 2517-2529. https://doi.org/10.1097/01.CCM.0000240233.01711.D9