Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Immediate Decrease in γ-AminoButyric Acid after Caffeine Intake in Adolescents: a Preliminary MRS Study

  • Hahn, Sanghyun (Hankuk Academy of Foreign Studies) ;
  • Kim, Yun Ho (Hankuk Academy of Foreign Studies) ;
  • Seo, Hyung Suk (Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine)
  • Received : 2017.03.08
  • Accepted : 2017.04.11
  • Published : 2017.06.30
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Abstract

In adolescents, sleep deprivation problem is getting worse, and increased caffeine consumption is considered to relieve the stress caused by sleep deprivation and academic burden. In this study, immediate neurologic effects of caffeine intake on adolescents were evaluated in three high school students using the ${\gamma}-aminobutyric$ acid (GABA)/creatine ratio on magnetic resonance spectroscopy (MRS). MEGA-PRESS MRS and TE 135 ms single voxel MRS were performed in the anterior cingulate cortex before and after drinking a cup of coffee, which contained 104 mg of caffeine. GABA and creatine were measured on LCModel 6.3, respectively. In all three students, GABA/creatine ratios were decreased after caffeine intake. The GABA/creatine ratios obtained before caffeine intake were decreased after caffeine intake in all the three adolescents. In this preliminary study, caffeine intake caused an immediate decrease in the GABA/creatine ratio in the brain and it may be related to the neurologic effects of caffeine on an adolescent's brain.

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References

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  1. Effects of Coffee and Its Components on the Gastrointestinal Tract and the Brain–Gut Axis vol.13, pp.1, 2017, https://doi.org/10.3390/nu13010088