생물정신의학 (Korean Journal of Biological Psychiatry)

  • 제24권2호
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  • Pages.75-81
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  • 2017
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  • 1225-8709(pISSN)
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  • 2005-7571(eISSN)
대한생물정신의학회 (The Korean Society of Biological Psychiatry)
권호 표지

강박장애의 치료받지 않은 유병기간에 따른 신경인지기능 이상 : 예비연구

Neurocognitive Dysfunction in Patients with Obsessive-Compulsive Disorder in Association of Duration of Untreated Illness : A Preliminary Study

  • 오상훈 (서울대학교병원 정신건강의학과) ;
  • 김성년 (서울대학교 의과대학 정신과학교실) ;
  • 한재욱 (서울대학교 의과대학 정신과학교실) ;
  • 이준희 (서울대학교병원 정신건강의학과) ;
  • 이태영 (서울대학교병원 정신건강의학과) ;
  • 신민섭 (서울대학교병원 정신건강의학과) ;
  • 권준수 (서울대학교병원 정신건강의학과)
  • Oh, Sang Hoon (Department of Psychiatry, Seoul National University Hospital) ;
  • Kim, Sung Nyun (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Han, Jaewook (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Lee, Junhee (Department of Psychiatry, Seoul National University Hospital) ;
  • Lee, Tae Young (Department of Psychiatry, Seoul National University Hospital) ;
  • Shin, Min-Sup (Department of Psychiatry, Seoul National University Hospital) ;
  • Kwon, Jun Soo (Department of Psychiatry, Seoul National University Hospital)
  • 투고 : 2017.03.02
  • 심사 : 2017.04.04
  • 발행 : 2017.05.31
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초록

Objectives Obsessive-compulsive disorder (OCD) is a chronic and disabling psychiatric disorder. The duration of untreated illness (DUI) has been suggested as one of the predictors of clinical course and outcome in various psychiatric disorders. There is increasing evidence that cognitive dysfunction is associated with the prognosis of OCD. The aim of this study was to investigate the influence of DUI on the neurocognitive functions in patients with OCD. Methods Sixty-two patients with a DSM-IV diagnosis of OCD from the outpatient clinic were included in this study. We defined the short DUI if the DUI was 2-year or less and the long DUI if it was longer than 2-year. Neurocognitive functions were assessed by visuospatial memory function test and 4 subsets of K-WAIS such as vocabulary, arithmetic, block design and picture arrangement. Differences in neurocognitive functions as well as clinical variables between OCD patients with short DUI and those with long DUI were investigated. Correlation analyses were also performed to determine the correlation between DUI and neurocognitive functions. Results Compared with the short DUI group, the long DUI group performed worse in the block design test, which measures executive function. The long DUI group also had a higher level of compulsive symptom severity than the short DUI group. However, the DUI was not correlated with neurocognitive functions. Conclusions Findings in this preliminary study suggest that the long DUI in patients with OCD is associated with more severe executive dysfunction. Studies with larger samples and longitudinal design are needed to further confirm the prognostic role of the DUI in OCD.

키워드

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