한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제21권1호
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  • Pages.93-100
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  • 2017
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  • 2465-9525(pISSN)
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  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
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Tangeretin Improves Glucose Uptake in a Coculture of Hypertrophic Adipocytes and Macrophages by Attenuating Inflammatory Changes

  • Shin, Hye-Sun (Department of Biology,Jeju National University, Jeju Special Self-Governing Province) ;
  • Kang, Seong-Il (Department of Biology,Jeju National University, Jeju Special Self-Governing Province) ;
  • Ko, Hee-Chul (Jeju Sasa Industry Development Agency, Jeju National University, Jeju Special Self-Governing Province) ;
  • Park, Deok-bae (Department of Medicine, Jeju National University, Jeju Special Self-Governing Province) ;
  • Kim, Se-Jae (Department of Biology,Jeju National University, Jeju Special Self-Governing Province)
  • 투고 : 2017.03.08
  • 심사 : 2017.03.12
  • 발행 : 2017.03.31
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초록

Obesity is characterized by a state of chronic low-grade inflammation and insulin resistance, which are aggravated by the interaction between hypertrophic adipocytes and macrophages. In this study, we investigated the effects of tangeretin on inflammatory changes and glucose uptake in a coculture of hypertrophic adipocytes and macrophages. Tangeretin decreased nitric oxide production and the expression of interleukin (IL)-6, $IL-1{\beta}$, tumor necrosis $factor-{\alpha}$, inducible nitric oxide synthase, and cyclooxygenase-2 in a coculture of 3T3-L1 adipocytes and RAW 264.7 cells. Tangeretin also increased glucose uptake in the coculture system, but did not affect the phosphorylation of insulin receptor substrate (IRS) and Akt. These results suggest that tangeretin improves insulin resistance by attenuating obesity-induced inflammation in adipose tissue.

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참고문헌

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