Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Association of Plasma Levels of Angiotensin-Converting Enzyme and Cytokines with Recurrent Depression : A Preliminary Study

안지오텐신전환효소 및 사이토카인 혈장 레벨과 재발성 우울증의 연관성 : 예비 연구

  • Sohn, Hoyoung (Department of Psychiatry, CHA Bundang Medical Center, CHA University) ;
  • Lee, Sun-Woo (Department of Psychiatry, CHA Bundang Medical Center, CHA University) ;
  • Kim, Min-Kyoung (Department of Psychiatry, CHA Bundang Medical Center, CHA University) ;
  • Lee, Kang Soo (Department of Psychiatry, CHA Bundang Medical Center, CHA University) ;
  • Lee, Sang-Hyuk (Department of Psychiatry, CHA Bundang Medical Center, CHA University) ;
  • Kwon, Min-Soo (Department of Pharmacology, School of Medicine, CHA University) ;
  • Kim, Borah (Department of Psychiatry, CHA Bundang Medical Center, CHA University)
  • 손호영 (차의과학대학교 분당차병원 정신건강의학과) ;
  • 이선우 (차의과학대학교 분당차병원 정신건강의학과) ;
  • 김민경 (차의과학대학교 분당차병원 정신건강의학과) ;
  • 이강수 (차의과학대학교 분당차병원 정신건강의학과) ;
  • 이상혁 (차의과학대학교 분당차병원 정신건강의학과) ;
  • 권민수 (차의과대학교 의학전문대학원 약리학교실) ;
  • 김보라 (차의과학대학교 분당차병원 정신건강의학과)
  • Received : 2016.12.07
  • Accepted : 2017.01.23
  • Published : 2017.02.28
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Abstract

Objectives Angiotensin-converting enzyme (ACE) gene and plasma levels of cytokines, such as tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), have previously been determined to be associated with depression. The purpose of this study was to investigate the association of plasma levels of ACE and cytokines with recurrent depression. Methods A total of 52 participants (14 male, 38 female, aged $43.9{\pm}14.0years$) were enrolled after being diagnosed with depression by experienced psychiatrists using the Mini International Neuropsychiatric Interview from the outpatient clinic of the Department of Psychiatry, CHA Bundang Medical Center. The participants completed blood sampling, the Hamilton Depression Rating Scale (HAMD), the Beck Depression Inventory, the Beck Anxiety Inventory, and the Scale for Suicidal Ideation. Results ACE plasma levels are higher in patients with recurrent depression ($27.4{\pm}10.4U/L$) than in patients with newly diagnosed depression ($19.1{\pm}7.7U/L$) (p = 0.004). The levels of cytokines, such as $TNF-{\alpha}$, IL-4, IL-6, IL-10, are not significantly different between the two groups. Additionally, the ACE plasma level is negatively correlated with a reduction in the HAMD over six weeks (r = -0.429, p = 0.046, n = 22). Conclusions The current findings show that plasma ACE levels may be associated with recurrent depression and further suggest that the renin-angiotensin system could play a role in recurrent depression.

Keywords

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