DOI QR코드

DOI QR Code

Effect of Walking Exercise with Blood Flow Restriction on Body Composition, Growth Hormone, and Muscle Damage Markers in Obese Women

혈류를 제한한 걷기운동이 비만여성의 신체조성과 성장호르몬, 근손상지표에 미치는 영향

  • Lee, Jang-Kyu (Dept. of Exercise Prescription & Rehabilitation, Dankook University)
  • 이장규 (단국대학교 운동처방재활학과)
  • Received : 2017.02.28
  • Accepted : 2017.04.07
  • Published : 2017.04.30

Abstract

Blood flow restriction(BFR) exercise is defined as low and short lengthexercise with pneumatic pressure belts at the top of the limbs. This study was conducted to investigate the effects of walking exercise with BFR on body composition, growth hormone, and muscle damage markers in obese women. Eleven obese women(> BMI 25kg/m2&> body fat 30%) wore pneumatic pressure belts at both femurs and performed walking exercise twice per day, 3days/wk for 4 week (walking 2min; resting 1min). Body weight, BMI and body fat significantly decreased after exercise(p<0.05), while% body fat was slightly decreased after exercise, although this difference was not significant. Growth hormones increased slightly after exercise, although not significantly. Muscle damage markers (CK(p<0.05), LDH(p<0.05) and K+(p<0.01 increased significantly after exercise, but Mb was did not change significantly. These results suggest that 4-weeks ofblood flow restriction exercisecould be used to prevent and treat obesity and related chronic diseases, as well as metabolic syndrome. Moreover, the effects were similar to those observed in response to high intensity resistance programs, despite the short period for which BFR were conducted.

혈류를 제한한 트레이닝이란, 특수제작 된 공압식 가압벨트를 사용해 사지의 혈류을 제한한 상태에서 저강도로, 단시간 운동하는 것을 말한다. 이 연구의 목적은 만성질환의 발병 위험성이 높은 직장 비만여성을 대상으로, 낮은 강도의 혈류를 제한한 4주간의 걷기트레이닝이 신체조성 및 성장호르몬, 근손상지표에 어떠한 영향을 미치는 지를 구명하고자 한다. 연구대상자는 BMI $25kg/m^2$와 체지방률 30% 이상의 직장 비만여성 11명으로 하였으며 혈류제한은 공압방식의 탄성벨트를 양쪽의 대퇴부위에 착용하고 압력을 조절하였다. 걷기프로그램은 트레드밀을 이용하여 실시하였으며(4주, 주 3일, 1일 2회), 2분 걷기와 1분 휴식으로 구성하여 총 5세트 반복하였다(4km/h, 5%). 이 연구의 결과에서 4주간의 혈류를 제한한 걷기트레이닝 후, 체중과 BMI, 지방량은 유의하게 감소되었으며(p<.05) 체지방률은 감소하는 경향을 보였으나 통계적 유의수준에는 도달하지 못하였다. 성장호르몬 또한 트레이닝 후, 증가하는 경향을 보였으나 통계적 유의차는 나타나지 않았다. 근손상지표 인 CK(p<.05)와 LDH(p<.05), $K^+$(p<.01)의 농도는 트레이닝 후, 유의하게 증가되었으며 Mb의 농도는 증가하는 경향을 보였지만 통계적 유의수준에는 도달하지 못하였다. 이상의 결과에서, 4주간의 혈류를 제한한 걷기트레이닝은 직장 비만여성들의 각종 만성성인질환 및 대사성 질환의 원인인 비만을 예방하고 치료하는데 효과가 있는 것으로 생각되며 이는 짧은 운동시간에도 불구하고 장시간의 운동 효과를 얻을 수 있는 것으로 사료된다.

Keywords

References

  1. Donnelly, J. E., Honas, J. J., Smith, B. K., Mayo, M. S., Gibson, C. A., Sullivan, D. K., Lee, J., Herrmann, S. D., Lambourne, K., Washburn, R. A, "Aerobic exercise alone results in clinically significant weight loss for men and women: midwest exercise trial 2", Obesity, 21, no. 3, pp. E219-28, 2013. DOI: https://doi.org/10.1002/oby.20145
  2. Rosenkilde, M., Auerbach, P., Reichkendler, M. H., Ploug, T., Stallknecht, B. M., & Sjodin, A, "Body fat loss and compensatory mechanisms in response to different doses of aerobic exercise--a randomized controlled trial in overweight sedentary males", Am J Physiol Regul Integr Comp Physiol, 15;303, no. 6, pp. R571-9, 2012. https://doi.org/10.1152/ajpregu.00141.2012
  3. Han, C. S., Lee, G. S., Lee, M. S., & Hwang, H. J, "The Effect of Changing the Order of Exercise Types on Body Composition and Blood Lipid in Obese Women". Korea Academia- Industrial cooperation Society, 10, no. 12, pp. 3888-3894, 2009. DOI: http://doi.org/10.5762/KAIS.2009.10.12.3888
  4. Lee, D. H., Oh, D. H., Zhang, S. A., Lee, J. K, "Effect of Exercise Type and Intensity on Insulin Resistance and Cardiovascular Disease Risk Factors in Obese Middle Aged Women" Korea Academia- Industrial cooperation Society, 17, no. 6, pp. 181-191, 2016. DOI: http://doi.org/10.5762/KAIS.2016.17.6.181
  5. Hamdy, R. C., Anderson, J. S., Whalen, K. E., & Harvill, L. M, "Regional differences in bone density of young men involved in different exercises", Med Sci Sports Exerc. 26, no. 7, pp. 884-8, 1994. DOI: https://doi.org/10.1249/00005768-199407000-00012
  6. American College of Sports Medicine, "Guidelines for Exercise Testing and Prescription, 7th, Baltomore, MI : Lippincott Williams & Wilkins, 2006.
  7. Weiss, L. W., Cureton. K. J., & Thompson, F. N, "Comparison of serum testosterone androstenedione responses to weight lifting in men and women", European Journal of Applied Physioligy and Occupational Physiology. 50, no. 3, pp. 413-419, 1983. DOI: https://doi.org/10.1007/BF00423247
  8. Beekley, M. D., Sato, Y., & Abe, T, "KAATSU-walk training increases serum bone-specific alkaline phosphatase in youn men", Int J KAATSU training Res, 1, pp. 77-81, 2005. https://doi.org/10.3806/ijktr.1.77
  9. Katch, F. I., & Drumm, S. S, "Effects of different modes of strength training on body composition and anthropometry", Clin Sports Med, 5, no. 3, pp. 413-59, 1986.
  10. Haykowsky, M. J., Findlay, J. M., & Ignaszewski, A. P, "Aneurysmal sub-ara chnoid hemorrhage associated with weight training:three case reports", Clin J Sport Med, 6, pp. 52-55, 1996. DOI: https://doi.org/10.1097/00042752-199601000-00011
  11. Abe, T., Kearns, C. F., & Sato, Y, "Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training", J Appl Physiol (1985), 2006 May;100, no. 5, pp. 1460-6, Erratum in: J Appl Physiol. 2008, 104, no. 4, pp. 1255, 2005. https://doi.org/10.1152/japplphysiol.01267.2005
  12. Takano, H., Morita, T., Iida, H., Asada, K., Kato, M., Uno, K., Hirose, K., Matsumoto, A., Takenaka, K., Hirata, Y., Eto, F., Nagai, R., Sato, Y., & Nakajima, T, "Hemodynamic and hormonal responses to a short-term low intensity resistance exercise with the reduction of muscle blood flow", Eur J Appl Physiol, 95, pp. 65-73, 2005. DOI: https://doi.org/10.1007/s00421-005-1389-1
  13. Takarada, Y., Tsuruta, T., & Ishii, N, "Cooperative effects of exercise and occlusive stimuli on muscular function in low-intensity resistance exercise with moderate vascular occlusion", Jap J Physiol, 54, pp. 585-92, 2004. DOI: https://doi.org/10.2170/jjphysiol.54.585
  14. Takarada, Y., Nakamura, Y., Aruga, S., Onda, T., Miyazaki, S., & Ishii, N, "Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion", J Appl Physiol, 88, pp. 61-65, 2000. https://doi.org/10.1152/jappl.2000.88.1.61
  15. Park, S. H., Ryu, H. S., & Kwon, Y. W, "Exercise and Healthy". Pegasus press, Seoul, Korea. (2014).
  16. Itoh, H., Ohkuwa, T., Yamazaki, Y., S himoda, T., Wakyama, A., Tamura, S., Yamamoto, T., Sato Y., & Miyamura, M, "Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training", International Journal of Sports Medicine, 21, no. 5, pp. 369-374, 2000. DOI: https://doi.org/10.1055/s-2000-3777
  17. Van Hall, G, "Lactate as a fuel for mitochondrial respiration. Acta Physiologica Scandinavica, 168, no. 4, pp. 643-656, 2000. DOI: https://doi.org/10.1046/j.1365-201x.2000.00716.x
  18. Falvo, M. J., & Bloomer, R. J, "Review of exercise -induced muscle injury: Relevance for athletic populations", Research in Sports Medicine, 14, no. 1, pp. 65-82, 2006. DOI: https://doi.org/10.1080/15438620500528380
  19. Godin, G., Desharnais, R., Valois, P., Lepage, L., Jobin, J., & Bradet, R, "Differences in perceived barriers to exercise between high and low intenders: observations among different populations. Am J Health Promotion. 8, pp. 279-284, 1994. DOI: https://doi.org/10.4278/0890-1171-8.4.279
  20. Trost, S. G., Owen, N., Bauman, A. E., Sallis, J. F., & Brown, W, "Correlates of adults' participation in physical activity: review and update", Med Sci Sports Exerc. 34, pp. 1996-2001, 2002. DOI: https://doi.org/10.1097/00005768-200212000-00020
  21. Marcus, B. H., Williams, D. M., Dubbert, P. M., Sallis, J. F., King, A. C., Yancey, A. K., Franklin, B. A., Buchner, D., Daniels, S. R., & Claytor, R. P., American Heart Association Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity).;American Heart Association Council on Cardiovascular Disease in the Young; Interdisciplinary Working Group on Quality of Care and Outcomes Research.. "Physical activity intervention studies: what we know and what we need to know: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity); Council on Cardiovascular Disease in the Young; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research, Circulation, 12;114, no. 24, pp. 2739-52. Review, Erratum in: Circulation, 2010 Jul 6;122, no. 1, pp. e8.2006. https://doi.org/10.1161/CIRCULATIONAHA.106.179683
  22. Jackson, A. S., Pollock, M. L., & Waed, A, "Generalized equations for predicting body density of women", Med Sci Sports Exerc, 12, no. 3, pp. 175-181, 1980. DOI: https://doi.org/10.1249/00005768-198023000-00009
  23. Siri, W, E, "Body composition from fluid spaces and densities :analysis of methods, In Brozek, J., Henschel, A.(eds, pp. Techniques for Measuring Body. Composition", Washington DC, National Academy of Sciences, 223-244, 1961.
  24. Sato, Y., Ishii, N., Nakajima, T., & Abe, T, "KAATSU Training. Theoretical and Practical Perspectives", goudan co, 2007.
  25. Takarada, Y., & Ishii, N, "Effects of low-intensity resistance exercise the shortest rest period on muscular function in middle-aged women", J Strength Cond Res, 16, pp. 123-128, 2002. DOI: https://doi.org/10.1519/00124278-200202000-00019
  26. Choi, H. M., & Lee, D. J, "Effect of Pressurization Training with Walking on Body Composition, Respiratory Function, and Cardiovascular Response in Middle-Aged Obese Women", Journal of Life Science, 22, no. 4, pp. 545-551, 2012. DOI: https://doi.org/10.5352/JLS.2012.22.4.545
  27. Seo, H. T., Ko, I. T., Kim, H. J., & Nho, H. S, "The effect of pressurization training with 2weeks term physical fitness and skeletal muscle function in elite snowboard athletes", The korea journal of sports science, 3, no. 4, pp. 1211-18, 2014.
  28. Booth, F. W., & Thomason, R. B, "Molecular and cellular adaptation of muscle in response to exercise: perspective of various models. Physiological reviews, 71, no. 2, pp. 541-585, 1991. https://doi.org/10.1152/physrev.1991.71.2.541
  29. Hamilton, M T., & Booth, F. W, "Skeletal muscle adaptation to exercise: a century of progress", Journal of applied physiology, 88, no. 1, pp. 327-332, 2000. https://doi.org/10.1152/jappl.2000.88.1.327
  30. Holloszy, J. O., & Booth, F. W., "Biochemical adaptations to endurance exercise in muscle", Annual review of physiology, 38, pp. 273-291, 1976. DOI: https://doi.org/10.1146/annurev.ph.38.030176.001421
  31. Scacchi, M., Pincelli, AI., & Cavagnini, F, "Growth hormone in obesity", Int J Obes Relat Metab Disord. 23, no. 3, pp. 260-71, 1999. DOI: https://doi.org/10.1038/sj.ijo.0800807
  32. Veldhuis, J. D., Iranmanesh, A., Ho, K. K., Waters, M. J., Johnson, M. L., & Lizarralde, G, "Dual defects in pulsatile growth hormone secretion and clearance subserve the hyposomatotropism of obesity in man", J Clin Endocrinol Metab. 72, no. 1, pp. 51-9, 1991. DOI: https://doi.org/10.1210/jcem-72-1-51
  33. Godfrey, R. J., Madgwick, Z., & Whyte, G. P, "The exercise-induced growth hormone response in athletes", Sports Med, 33, no. 8, pp. 599-613, 2003. DOI: https://doi.org/10.2165/00007256-200333080-00005
  34. Ozaki, H., Loenneke, J. P., & Abe, T, "Blood flow-restricted walking in older women: does the acute hormonal response associate with muscle hypertrophy?", Clin Physiol Funct Imaging, Oct 30. [Epub ahead of print], 2015. DOI: https://doi.org/10.1111/cpf.12312
  35. Williams, T., Berelowitz, M., Joffe, S. N., Thorner, M. O., Rivier, J., Vale, W., & Frohman, L. A, "Impaired growth hormone responses to growth hormone-releasing factor in obesity. A pituitary defect reversed with weight reduction", N Engl J Med, 29, no. 22, pp. 1403-7, 1984. DOI: https://doi.org/10.1056/NEJM198411293112203
  36. Tanaka, K., Inoue, S., Numata, K., Okazaki, H., Nakamura, S., & Takamura, Y, "Very-low calorie diet-induced weight reduction reverses impaired growth hormone secretion response to growth hormone-releasing hormone, arginine, and L-dopa in obesity", Metabolism, 39, no. 9, pp. 892-6, 1990. DOI: https://doi.org/10.1016/0026-0495(90)90296-O
  37. Rasmussen, M. H., Hvidberg, A., Juul, A., Main, K. M., Gotfredsen, A., Skakkebaek, N. E., Hilsted, J., & Skakkebae, N. E, "Massive weight loss restores 24-hour growth hormone release profiles an serum insulin-like growth factor-I levels in obese subjects", J Clin Endocrinol Metab, 80, no. 8, pp. 2446, 1995. DOI: https://doi.org/10.1210/jcem.80.4.7536210
  38. Clarkson, P. M., & Hubal, M. J, "Exercise-induced muscle damage in humans", Am J Phys Med Rehabil, 81, no. 11 Suppl, pp. S52-69, 2002. DOI: https://doi.org/10.1097/00002060-200211001-00007
  39. Sayers, S. P., & Clarkson, P. M, "Exercise-induced rhabdomyolysis", Curr Sports Med Rep, 1, no. 2, pp. 59-60, 2002. DOI: https://doi.org/10.1249/00149619-200204000-00001
  40. Proske, U., & Morgan, D. L, "Muscle damage from eccentric exercise: mechanism, mechanical signs, adaptation and clinical applications", J Physiol, 537(Pt2, pp. 333-45, 2001. DOI: https://doi.org/10.1111/j.1469-7793.2001.00333.x
  41. Clarkson, P. M., Kearns, A. K., Rouzier, P., Rubin, R., & Thompson, P. D, "Serum creatine kinase levels and renal function measures in exertional muscle damage", Med Sci Sports Exerc, 38, no. 4, pp. 623-7, 2006. DOI: https://doi.org/10.1249/01.mss.0000210192.49210.fc
  42. Lee, J., & Clarkson, P. M, "Plasma creatine kinase activity and glutathione after eccentric exercise. Med Sci Sports Exerc, 35, no. 6, pp. 930-6, 2003. DOI: https://doi.org/10.1249/01.MSS.0000069553.47739.36
  43. Nosaka, K., & Clarkson, P. M, "Changes in indicators of inflammation after eccentric exercise of the elbow flexors. Med Sci Sports Exerc, 28, no. 8, pp. 953-61, 1996. DOI: https://doi.org/10.1097/00005768-199608000-00003
  44. Marieb, E. N, "Human anatomy and physiology", third edition, pp:856. The benjamin/cumming publishing company. california. USA, 1995.
  45. Piitulainen, H., Komi, P., Linnamo, V., & Avela, J, "Sarcolemmal excitability as investigated with M-waves after eccentric exercise in humans", J Electromyogr Kinesiol, 18, no. 4, pp. 672-81, 2008. DOI: https://doi.org/10.1016/j.jelekin.2007.01.004
  46. Sejersted, O. M., & Sjogaard, G, "Dynamics and consequences of potassium shifts in skeletal muscle and heart during exercise", Physiol Rev, 80, no. 4, pp. 1411-81, 2000. https://doi.org/10.1152/physrev.2000.80.4.1411
  47. Friden, J., Sjostrom, M., & Ekblom, B, "A morphological study of delayed muscle soreness", Experientia. 15;37, no. 5, pp. 506-7, 1981. https://doi.org/10.1007/BF01986165
  48. Barash, I. A., Peters, D., Friden, J., Lutz, G. J., & Lieber, R. L, "Desmin cytoskeletal modifications after a bout of eccentric exercise in the rat", Am J Physiol Regul Integr Comp Physiol, 283, no. 4, pp. R958-63, 2002. DOI: https://doi.org/10.1152/ajpregu.00185.2002
  49. Warren, G. L., Ingalls, C. P., Lowe, D. A., & Armstrong, R. B, "Excitation-contraction uncoupling: major role in contraction-induced muscle injury", Exerc Sport Sci Rev, 29, no. 2, pp. 82-7, 2001. DOI: https://doi.org/10.1097/00003677-200104000-00008
  50. Kim, K. S., Park, S. H., Huh, Y., & Park, M. R, "Search for the trend of study and possibility of field application on resistance training with blood flow restriction", The Korean Journal of Sports Science, 20, no. 5, pp. 1047-1065, 2011.