Journal of Korean Neurosurgical Society

  • 제60권3호
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  • Pages.355-361
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  • 2017
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  • 2005-3711(pISSN)
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  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
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Effects of Quercetin and Mannitol on Erythropoietin Levels in Rats Following Acute Severe Traumatic Brain Injury

  • Kalemci, Orhan (Department of Neurosurgery, School of Medicine and Hospital, Dokuz Eylul University) ;
  • Aydin, Hasan Emre (Department of Pharmacology, Eskisehir Osmangazi University) ;
  • Kizmazoglu, Ceren (Department of Neurosurgery, School of Medicine and Hospital, Dokuz Eylul University) ;
  • Kaya, Ismail (Department of Neurosurgery, Kilis State Hospital) ;
  • Yilmaz, Hulya (Department of Biostatistics and Medical Informatics, Eskisehir Osmangazi University) ;
  • Arda, Nuri M (Department of Neurosurgery, School of Medicine and Hospital, Dokuz Eylul University)
  • 투고 : 2016.05.31
  • 심사 : 2016.11.29
  • 발행 : 2017.05.01
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초록

Objective : The aim of this study to investigate the normal values of erythropoietin (EPO) and neuroprotective effects of quercetin and mannitol on EPO and hematocrit levels after acute severe traumatic brain injury (TBI) in rat model. Methods : A weight-drop impact acceleration model of TBI was used on 40 male Wistar rats. The animals were divided into sham (group I), TBI (group II), TBI+quercetin (50 mg/kg intravenously) (group III), and TBI+mannitol (1 mg/kg intravenously) (group IV) groups. The malondialdehyde, glutathione peroxidase, catalase, EPO, and hematocrit levels were measured 1 and 4 hour after injury. Two-way repeated measures analysis of variance and Tukey's test were used for statistical analysis. Results : The malondialdehyde levels decreased significantly after administration of quercetin and mannitol compared with those in group II. Catalase and glutathione peroxidase levels increased significantly in groups III and IV. Serum EPO levels decreased significantly after mannitol but not after quercetin administration. Serum hematocrit levels did not change significantly after quercetin and mannitol administration 1 hour after trauma. However, mannitol administration decreased serum hematocrit levels significantly after 4 hour. Conclusion : This study suggests that quercetin may be a good alternative treatment for TBI, as it did not decrease the EPO levels.

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참고문헌

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