생약학회지 (Korean Journal of Pharmacognosy)

  • 제48권1호
  • /
  • Pages.31-37
  • /
  • 2017
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

글루타메이트로 유발한 세포독성에 대한 삼채추출물의 뇌세포 보호 효과

Effects of Allium hookeri Extracts on Glutamate-induced Neurotoxicity in HT22 Cells

  • 김지윤 (경기대학교 일반대학원 대체의학과) ;
  • 고원민 (원광대학교 약학대학) ;
  • 김애정 (경기대학교 일반대학원 대체의학과)
  • Kim, Ji-Yun (The Graduate School of Alternative Medicine, Kyonggi University) ;
  • Ko, Wonmin (College of Pharmacy, Wonkwang University) ;
  • Kim, Ae-Jung (The Graduate School of Alternative Medicine, Kyonggi University)
  • 투고 : 2016.11.18
  • 심사 : 2017.03.16
  • 발행 : 2017.03.31
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초록

Glutamate-induced oxidative stress results in neuro-degenerative disorders in many central nervous system (CNS) such as Alzheimer's disease, ischemia, Huntington's disease, and Parkinson's disease. Our study was performed to investigate neuroprotective effects of Allium hookeri extracts (leaf, root, and whole) on glutamate-induced HT22 cells. In this study, ethanol extract of A. hookeri showed the outstanding neuroprotective effect in HT22 cells. In addition, we found that ethanol extract of A. hookeri root increased heme oxygenase (HO)-1 in HT22 cells. Moreover, ethanol extract of A. hookeri root also upregulated nuclear accumulation of nuclear factor E2-related factor 2 (Nrf2) in HT22 cells. These results demonstrate that ethanol extract of A. hookeri root contributes neuroprotective effects against glutamate-induced oxidative stress in HT22 cells, via Nrf2-mediated HO-1 expression. Our study suggests that ethanol extract of A. hookeri root could be the potential agent for the treatment of many neuro-degenerative diseases.

키워드

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