Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Aldose reductase inhibitory activity of quercetin from the stems of Rhododendron mucronulatum for. albiflorum

  • Lee, Jaemin (Department of Integrative Plant Science, Chung-Ang University) ;
  • Ryu, Hyun-Sung (Pyeongtaek High School) ;
  • Rodriguez, Joyce P. (Department of Integrative Plant Science, Chung-Ang University) ;
  • Lee, Sanghyun (Department of Integrative Plant Science, Chung-Ang University)
  • Received : 2016.10.19
  • Accepted : 2016.11.01
  • Published : 2017.03.30
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Abstract

The methanol extract of Rhododendron mucronulatum for. albiflorum (RMFA) stems inhibited aldose reductase (AR) activity. The RMFA fractions obtained by stepwise extraction with solvents of different polarity were tested for AR inhibition in vitro using the lens of a rat. Among them, the ethyl acetate (EtOAc) fraction inhibited AR more than the other fractions. Quercetin (1) from the EtOAc fraction showed a high AR inhibition with $IC_{50}$ of $2.11{\mu}M$. The stems of RMFA contained the highest amount (5.12 mg/g extract) of quercetin. Our results suggest that RMFA, which contained quercetin, could be a useful material for the development of supplementary functional foods.

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References

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