Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지
DOI QR코드

DOI QR Code

Optimization of Extraction Conditions for Active Compounds of Herbal Medicinal Formula, DF, by Response Surface Methodology

  • Jeong, Birang (College of Pharmacy, Kangwon National University) ;
  • Choi, Seong Yeon (College of Pharmacy, Kangwon National University) ;
  • Jang, Hyeon Seok (College of Pharmacy, Kangwon National University) ;
  • Yoo, Guijae (College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University) ;
  • Kim, Seung Hyun (College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University) ;
  • Kim, Jung-Hwan (Department of Pharmacology, School of Medicine, Institute of Health Sciences, Gyeongsang National University) ;
  • Kwon, Yong Soo (College of Pharmacy, Kangwon National University) ;
  • Roh, Jong Seong (Department of Formula Sciences, College of Korean Medicine, Dong-Eui University) ;
  • Yoon, Yoosik (Department of Microbiology, College of Medicine, Chung-Ang University) ;
  • Shin, Soon Shik (Department of Formula Sciences, College of Korean Medicine, Dong-Eui University) ;
  • Yang, Heejung (College of Pharmacy, Kangwon National University)
  • Received : 2016.08.03
  • Accepted : 2016.10.06
  • Published : 2017.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

DF formula is comprised of three traditional herbs, Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizon, and locally used for treating of the metabolic diseases, such as obesity and diabetes in Korea. We tried to optimize the extraction conditions of two major components, (-)-ephedrine and (+)-pseudoephedrine, in DF formula using response surface methodology with Box-Behnken design (BBD). The experimental conditions with 70% for EtOH concentrations, 4.8 hour for extraction hours and 8.7 times for the solvent to material ratio were suggested for the optimized extraction of DF formula with the highest amounts of (-)-ephedrine and (+)-pseudoephedrine in the designed model.

Keywords

References

  1. Uzuner, H.; Bauer, R.; Fan, T. P.; Guo, D. A.; Dias, A.; El-Nezami, H.; Efferth, T.; Williamson, E. M.; Heinrich, M.; Robinson, N.; Hylands, P. J.; Hendry, B. M.; Cheng, Y. C.; Xu, Q. J. Ethnopharmacol. 2012, 140, 458-468. https://doi.org/10.1016/j.jep.2012.02.028
  2. Ferreira, S. L.; Bruns, R. E.; da Silva, E. G.; Dos Santos, W. N.; Quintella, C. M.; David, J. M.; de Andrade, J. B.; Breitkreitz, M. C.; Jardim, I. C.; Neto, B. B. J. Chromatogr. A 2007, 1158, 2-14. https://doi.org/10.1016/j.chroma.2007.03.051
  3. Roman, M. C. J. AOAC Int. 2004, 87, 1-14.
  4. Ma, G.; Bavadekar, S. A.; Davis, Y. M.; Lalchandani, S. G.; Nagmani, R.; Schaneberg, B. T.; Khan, I. A.; Feller, D. R. J. Pharmacol. Exp. Ther. 2007, 322, 214-221. https://doi.org/10.1124/jpet.107.120709
  5. Fleming, R. M. Expert Opin. Drug Saf. 2008, 7, 749-759. https://doi.org/10.1517/14740330802510915
  6. Stohs, S. J.; Badmaev, V. Phytother. Res. 2016, 30, 732-740. https://doi.org/10.1002/ptr.5583
  7. Pittler, M. H.; Schmidt, K.; Ernst, E. Obes. Rev. 2005, 6, 93-111. https://doi.org/10.1111/j.1467-789X.2005.00169.x
  8. Stohs, S. J. Plast. Reconstr. Surg. 2013, 132, 876e-877e. https://doi.org/10.1097/PRS.0b013e3182a4c4a6
  9. Aichner, D.; Ganzera, M. Talanta 2015, 144, 1239-1244. https://doi.org/10.1016/j.talanta.2015.08.011
  10. Wang, H.; Song, H.; Yue, J.; Li, J.; Hou, Y. B.; Deng, J. L. Cochrane Database Syst. Rev. 2012, CD008000.
  11. Papageorgiou, V. P.; Assimopoulou, A. N.; Ballis, A. C. Curr. Med. Chem. 2008, 15, 3248-3267. https://doi.org/10.2174/092986708786848532
  12. Hu, Y.; Jiang, Z.; Leung, K. S.; Zhao, Z. Anal. Chim. Acta 2006, 577, 26-31. https://doi.org/10.1016/j.aca.2006.06.031
  13. Aslan, N; Cebeci, Y. Fuel 2007, 86, 90-97. https://doi.org/10.1016/j.fuel.2006.06.010
  14. Schaneberg, B. T.; Crockett, S.; Bedir, E.; Khan, I. A. Phytochemistry 2003, 62, 911-918. https://doi.org/10.1016/S0031-9422(02)00716-1
  15. Ichikawa, M.; Udayama, M.; Imamura, K.; Shiraishi, S.; Matsuura, H. Chem. Pharm. Bull. 2003, 51, 635-639. https://doi.org/10.1248/cpb.51.635

Cited by

  1. Simultaneous Analysis of Four Standards of The Herbal Formula, DF-02, of Ephedra intermedia and Rheum palmatum, using by High Performance Liquid Chromatography-Ultraviolet Detector (HPLC-UVD) vol.25, pp.2, 2017, https://doi.org/10.20307/nps.2019.25.2.111
  2. A Network Pharmacology Approach to Investigate the Anticancer Mechanism and Potential Active Ingredients of Rheum palmatum L. Against Lung Cancer via Induction of Apoptosis vol.11, pp.None, 2017, https://doi.org/10.3389/fphar.2020.528308
  3. Stilbenes with Potent Protein Tyrosine Phosphatase-1B Inhibitory Activity from the Roots of Polygonum multiflorum vol.83, pp.2, 2017, https://doi.org/10.1021/acs.jnatprod.9b00777