References
- Barcia, C., Ros, C.M., Annese, V., Gomez, A., Ros-Bernal, F., Aguado- Llera, D., Martinez-Pagan, M.E., de Pablos, V., Fernandez-Villalba, E., and Herrero, M.T. (2012). IFN-gamma signaling, with the synergistic contribution of TNF-alpha, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease. Cell. Death Dis. 3, e379. https://doi.org/10.1038/cddis.2012.123
- Block, M.L. (2014). Neuroinflammation: modulating mighty microglia. Nat. Chem Biol. 10, 988-989. https://doi.org/10.1038/nchembio.1691
- Carnevale, K.A., and Cathcart, M.K. (2001). Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1. J. Immunol. 167, 3414-3421. https://doi.org/10.4049/jimmunol.167.6.3414
- Castellano, E., and Downward, J. (2010). Role of RAS in the regulation of PI 3-kinase. Curr. Top Microbiol. Immunol. 346, 143-169.
- Chen, L., Iijima, M., Tang, M., Landree, M.A., Huang, Y.E., Xiong, Y., Iglesias, P.A., and Devreotes, P.N. (2007). PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev. Cell 12, 603-614. https://doi.org/10.1016/j.devcel.2007.03.005
- Colton, C., and Wilcock, D.M. (2010). Assessing activation states in microglia. CNS Neurol. Disord. Drug Targets 9, 174-191. https://doi.org/10.2174/187152710791012053
- Davalos, D., Grutzendler, J., Yang, G., Kim, J.V., Zuo, Y., Jung, S., Littman, D.R., Dustin, M.L., and Gan, W.B. (2005). ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 8, 752-758. https://doi.org/10.1038/nn1472
- Delgado, M. (2003). Inhibition of interferon (IFN) gamma-induced Jak-STAT1 activation in microglia by vasoactive intestinal peptide: inhibitory effect on CD40, IFN-induced protein-10, and inducible nitric-oxide synthase expression. J. Biol. Chem. 278, 27620-27629. https://doi.org/10.1074/jbc.M303199200
- Dubyak, G.R., and el-Moatassim, C. (1993). Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides. Am. J. Physiol. 265, C577-606. https://doi.org/10.1152/ajpcell.1993.265.3.C577
- Gordon, S. (2003). Alternative activation of macrophages. Nat. Rev. Immunol. 3, 23-35. https://doi.org/10.1038/nri978
- Haugh, J.M., Codazzi, F., Teruel, M., and Meyer, T. (2000). Spatial sensing in fibroblasts mediated by 3' phosphoinositides. J. Cell. Biol. 151, 1269-1280. https://doi.org/10.1083/jcb.151.6.1269
- Haynes, S.E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M.E., Gan, W.B., and Julius, D. (2006). The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat. Neurosci. 9, 1512-1519. https://doi.org/10.1038/nn1805
- Honda, S., Sasaki, Y., Ohsawa, K., Imai, Y., Nakamura, Y., Inoue, K., and Kohsaka, S. (2001). Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J. Neurosci. 21, 1975-1982. https://doi.org/10.1523/JNEUROSCI.21-06-01975.2001
- Inoue, K. (2002). Microglial activation by purines and pyrimidines. Glia 40, 156-163. https://doi.org/10.1002/glia.10150
- Irino, Y., Nakamura, Y., Inoue, K., Kohsaka, S., and Ohsawa, K. (2008). Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia. J. Neurosci. Res. 86, 1511-1519. https://doi.org/10.1002/jnr.21610
- Ito, S., Kimura, K., Haneda, M., Ishida, Y., Sawada, M., and Isobe, K. (2007). Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway. Exp. Gerontol. 42, 532-537. https://doi.org/10.1016/j.exger.2006.11.012
- Kettenmann, H., and Verkhratsky, A. (2011). [Neuroglia--living nerve glue]. Fortschr. Neurol. Psychiatr 79, 588-597. https://doi.org/10.1055/s-0031-1281704
- Kim, W.K., Kan, Y., Ganea, D., Hart, R.P., Gozes, I., and Jonakait, G.M. (2000). Vasoactive intestinal peptide and pituitary adenylyl cyclase-activating polypeptide inhibit tumor necrosis factor-alpha production in injured spinal cord and in activated microglia via a cAMP-dependent pathway. J. Neurosci. 20, 3622-3630. https://doi.org/10.1523/JNEUROSCI.20-10-03622.2000
- Kreutzberg, G.W. (1996). Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19, 312-318. https://doi.org/10.1016/0166-2236(96)10049-7
- Lee, S., and Chung, C.Y. (2009). Role of VASP phosphorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation. Mol. Cell Neurosci. 42, 382-390. https://doi.org/10.1016/j.mcn.2009.08.010
- Lee, S.H., Schneider, C., Higdon, A.N., Darley-Usmar, V.M., and Chung, C.Y. (2011). Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis. Traffic 12, 878-889. https://doi.org/10.1111/j.1600-0854.2011.01195.x
- Lee, S.H., Hollingsworth, R., Kwon, H.Y., Lee, N., and Chung, C.Y. (2012). beta-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser(83) and microglia chemotaxis. Glia 60, 1366-1377. https://doi.org/10.1002/glia.22355
- Lee, S.H., Sud, N., Lee, N., Subramaniyam, S., and Chung, C.Y. (2016). Regulation of Integrin alpha6 Recycling by Calciumindependent Phospholipase A2 (iPLA2) to Promote Microglia Chemotaxis on Laminin. J. Biol. Chem. 291, 23645-23653. https://doi.org/10.1074/jbc.M116.732610
- Lu, D.Y., Tang, C.H., Yeh, W.L., Wong, K.L., Lin, C.P., Chen, Y.H., Lai, C.H., Chen, Y.F., Leung, Y.M., and Fu, W.M. (2009). SDF-1alpha upregulates interleukin-6 through CXCR4, PI3K/Akt, ERK, and NFkappaB- dependent pathway in microglia. Eur J. Pharmacol. 613, 146-154. https://doi.org/10.1016/j.ejphar.2009.03.001
- Mishra, R.S., Carnevale, K.A., and Cathcart, M.K. (2008). iPLA2beta: front and center in human monocyte chemotaxis to MCP-1. J. Exp. Med. 205, 347-359. https://doi.org/10.1084/jem.20071243
- Nasu-Tada, K., Koizumi, S., and Inoue, K. (2005). Involvement of beta1 integrin in microglial chemotaxis and proliferation on fibronectin: different regulations by ADP through PKA. Glia 52, 98-107. https://doi.org/10.1002/glia.20224
- Neary, J.T., Baker, L., Jorgensen, S.L., and Norenberg, M.D. (1994). Extracellular ATP induces stellation and increases glial fibrillary acidic protein content and DNA synthesis in primary astrocyte cultures. Acta Neuropathol. 87, 8-13. https://doi.org/10.1007/BF00386249
- Nimmerjahn, A., Kirchhoff, F., and Helmchen, F. (2005). Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318. https://doi.org/10.1126/science.1110647
- Ohsawa, K., Irino, Y., Nakamura, Y., Akazawa, C., Inoue, K., and Kohsaka, S. (2007). Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis. Glia 55, 604-616. https://doi.org/10.1002/glia.20489
- Parent, C.A., Blacklock, B.J., Froehlich, W.M., Murphy, D.B., and Devreotes, P.N. (1998). G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95, 81-91. https://doi.org/10.1016/S0092-8674(00)81784-5
- Prinz, M., and Priller, J. (2014). Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat. Rev. Neurosci. 15, 300-312. https://doi.org/10.1038/nrn3722
- Rickert, P., Weiner, O.D., Wang, F., Bourne, H.R., and Servant, G. (2000). Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol. 10, 466-473. https://doi.org/10.1016/S0962-8924(00)01841-9
- Sasaki, A.T., and Firtel, R.A. (2006). Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR. Eur. J. Cell Biol. 85, 873-895. https://doi.org/10.1016/j.ejcb.2006.04.007
- Sasaki, Y., Hoshi, M., Akazawa, C., Nakamura, Y., Tsuzuki, H., Inoue, K., and Kohsaka, S. (2003). Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain. Glia 44, 242-250. https://doi.org/10.1002/glia.10293
- Shankar, H., Garcia, A., Prabhakar, J., Kim, S., and Kunapuli, S.P. (2006). P2Y12 receptor-mediated potentiation of thrombin-induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation. J. Thromb. Haemost. 4, 638-647. https://doi.org/10.1111/j.1538-7836.2006.01789.x
- Stence, N., Waite, M., and Dailey, M.E. (2001). Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33, 256-266. https://doi.org/10.1002/1098-1136(200103)33:3<256::AID-GLIA1024>3.0.CO;2-J
- Streit, W.J. (2002). Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40, 133-139. https://doi.org/10.1002/glia.10154
- Streit, W.J., Graeber, M.B., and Kreutzberg, G.W. (1988). Functional plasticity of microglia: a review. Glia 1, 301-307. https://doi.org/10.1002/glia.440010502
- Stuart, L.M., Bell, S.A., Stewart, C.R., Silver, J.M., Richard, J., Goss, J.L., Tseng, A.A., Zhang, A., El Khoury, J.B., and Moore, K.J. (2007). CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex. J. Biol. Chem. 282, 27392-27401. https://doi.org/10.1074/jbc.M702887200
- Suzumura, A. (2013). [Microglia in pathophysiology of neuroimmunological disorders]. Nihon. Rinsho. 71, 801-806.
- Swiatkowski, P., Murugan, M., Eyo, U.B., Wang, Y., Rangaraju, S., Oh, S.B., and Wu, L.J. (2016). Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury. Neuroscience 318, 22-33. https://doi.org/10.1016/j.neuroscience.2016.01.008
- Tatsumi, E., Yamanaka, H., Kobayashi, K., Yagi, H., Sakagami, M., and Noguchi, K. (2015). RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain. Glia 63, 216-228. https://doi.org/10.1002/glia.22745
- Town, T., Nikolic, V., and Tan, J. (2005). The microglial "activation" continuum: from innate to adaptive responses. J. Neuroinflammation 2, 24. https://doi.org/10.1186/1742-2094-2-24
- van Haastert, P.J., Keizer-Gunnink, I., and Kortholt, A. (2007). Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis. J. Cell Biol. 177, 809-816. https://doi.org/10.1083/jcb.200701134
- Wang, F., Herzmark, P., Weiner, O.D., Srinivasan, S., Servant, G., and Bourne, H.R. (2002). Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat. Cell Biol. 4, 513-518. https://doi.org/10.1038/ncb810
- Wang, Y.P., Wu, Y., Li, L.Y., Zheng, J., Liu, R.G., Zhou, J.P., Yuan, S.Y., Shang, Y., and Yao, S.L. (2011). Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-kappaB and MAPKs in BV-2 microglial cells. J. Neuroinflammation 8, 95. https://doi.org/10.1186/1742-2094-8-95
- Weiner, O.D., Neilsen, P.O., Prestwich, G.D., Kirschner, M.W., Cantley, L.C., and Bourne, H.R. (2002). A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat. Cell Biol. 4, 509-513. https://doi.org/10.1038/ncb811
- Zhang, X., Qin, J., Zou, J., Lv, Z., Tan, B., Shi, J., Zhao, Y., Ren, H., Liu, M., Qian, M., et al. (2016). Extracellular ADP facilitates monocyte recruitment in bacterial infection via ERK signaling. Cell Mol. Immunol. [Epub ahead of print]
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