The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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The oncogenic effects of p53-inducible gene 3 (PIG3) in colon cancer cells

  • Park, Seon-Joo (Laboratory of Genomic Instability and Cancer Therapeutics, Cancer Mutation Research Center) ;
  • Kim, Hong Beum (Laboratory of Genomic Instability and Cancer Therapeutics, Cancer Mutation Research Center) ;
  • Kim, Jeeho (Laboratory of Genomic Instability and Cancer Therapeutics, Cancer Mutation Research Center) ;
  • Park, Sanggon (Department of Internal Medicine, Hemato-oncology Chosun University School of Medicine) ;
  • Kim, Seok Won (Department of Neurosurgery, Chosun University School of Medicine) ;
  • Lee, Jung-Hee (Laboratory of Genomic Instability and Cancer Therapeutics, Cancer Mutation Research Center)
  • Received : 2017.01.25
  • Accepted : 2017.02.03
  • Published : 2017.03.01
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Abstract

The p53-inducible gene 3 (PIG3), initially identified as a gene downstream of p53, plays an important role in the apoptotic process triggered by p53-mediated reactive oxygen species (ROS) production. Recently, several studies have suggested that PIG3 may play a role in various types of cancer. However, the functional significance of PIG3 in cancer remains unclear. Here, we found that PIG3 was highly expressed in human colon cancer cell lines compared to normal colon-derived fibroblasts. Therefore, we attempted to elucidate the functional role of PIG3 in colon cancer. PIG3 overexpression increases the colony formation, migration and invasion ability of HCT116 colon cancer cells. Conversely, these tumorigenic abilities were significantly decreased in in vitro studies with PIG3 knockdown HCT116 cells. PIG3 knockdown also attenuated the growth of mouse xenograft tumors. These results demonstrate that PIG3 is associated with the tumorigenic potential of cancer cells, both in vitro and in vivo, and could play a key oncogenic role in colon cancer.

Keywords

References

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