Asian-Australasian Journal of Animal Sciences

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of age on intestinal phosphate transport and biochemical values of broiler chickens

  • Li, Jianhui (College of Animal Science and Veterinary Medicine, Shanxi Agricultural University) ;
  • Yuan, Jianmin (State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University) ;
  • Miao, Zhiqiang (College of Animal Science and Veterinary Medicine, Shanxi Agricultural University) ;
  • Guo, Yuming (State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University)
  • Received : 2016.07.18
  • Accepted : 2016.09.21
  • Published : 2017.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: The objective of this experiment was to characterize the mRNA expression profile of type IIb sodium-inorganic phosphate cotransporter (NaPi-IIb) and the biochemical values of serum alkaline phosphatase (AKP), calcium, inorganic phosphorus, tibial ash and minerals of broiler chickens with aging. Methods: A total of 56 one-day-old Arbor Acres male broiler chickens were used. Broiler chickens were weighed and samples were collected weekly from day 1. Results: The result showed that before the growth inflection point, ash, calcium, and phosphorus content in the tibia of broiler chickens increased with growth (before 3 weeks of age), although there were no significant differences in chicks at different ages in the later period of the experiment and weight gain rate was relatively slow at this stage (4 to 6 weeks). NaPi-IIb gene expression in the small intestine in the early growth stage was higher than that in the later growth stage. Expression of calbindin and the vitamin D receptor protein in the intestinal mucosa increased with age in the duodenum and jejunum. Serum AKP activity first increased and subsequently decreased after peaking at 1 week of age, but there was no significant difference after 3 weeks of age. Conclusion: These results show that compared with the early growth stage, the weight-gain rate of broiler chickens in the late growth stage gradually decreased with gradual tibia maturation, along with weaker positive transport of phosphorus in the intestine and reinforced re-absorption of phosphorus in the kidney, which might be the reason that phosphorus requirement in the late growth stage was decreased.

Keywords

References

  1. Armbrecht HJ. Effect of age on calcium and phosphate absorption. Role of 1,25-dihydroxyvitamin D. Miner Electrol Metab 1990;16: 159-66.
  2. Barreiro FR, Sagula AL, Junqueira OM, Pereira GT, Baraldi-Artoni SM. Densitometric and biochemical values of broiler tibias at different ages. Poult Sci 2009;88:2644-48. https://doi.org/10.3382/ps.2008-00079
  3. Marks J, Debnam ES, Unwin RJ. Phosphate homeostasis and the renal-gastrointestinal axis. Am J Physiol-Renal 2010;299:F285-F96. https://doi.org/10.1152/ajprenal.00508.2009
  4. Hattenhauer O, Traebert M, Murer H, Biber J. Regulation of small intestinal Na-Pi type IIb cotransporter by dietary phosphate intake. Am J Physiol-Gastr L 1999;277:G756-G62.
  5. Murer H, Forster I, Biber J. The sodium phosphate cotransporter family SLC34. Pflugers Arch 2004;447: 763-67. https://doi.org/10.1007/s00424-003-1072-5
  6. Michigami T. Regulatory mechanism of circulating inorganic phosphate. Clin Calcium 2016;26:193-8.
  7. Waldroup PW, Kersey JH, Saleh EA, et al. Nonphytate phosphorus requirement and phosphorus excretion of broiler chicks fed diets composed of normal or high available phosphate corn with and without microbial phytase. Poult Sci 2000;79:1451-59. https://doi.org/10.1093/ps/79.10.1451
  8. Dhandu AS, Angel R. Broiler nonphytin phosphorus requirement in the finisher and withdrawal phases of a commercial four-phase feeding system. Poult Sci 2003;82:1257-65. https://doi.org/10.1093/ps/82.8.1257
  9. Howe JC, Beecher GR. Dietary protein and phosphorus: effect on calcium and phosphorus metabolism in bone, blood and muscle of the rat. J Nutr 1983;113:2085-95. https://doi.org/10.1093/jn/113.10.2085
  10. Xu H, Bai L, Collins JF, Ghishan FK. Age-dependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-$(OH)_2$ vitamin $D_3$. Am J Physiol Cell Physiol 2002;282:487-93. https://doi.org/10.1152/ajpcell.00412.2001
  11. Bar A, Shinder D, Yosefi S, Vax E, Plavnik I. Metabolism and requirements for calcium and phosphorus in the fast-growing chicken as affected by age. Br J Nutr 2003;89:51-60. https://doi.org/10.1079/BJN2002757
  12. Li JH, Yuan JM, Guo YM, et al. The effect of dietary nutrient density on growth performance, physiological parameters and small intestinal type IIb sodium phosphate co-transporter expression in broilers. J Anim Sci Biotech 2011;2:102-10.
  13. Li JH, Yuan JM, Miao ZQ, et al. Effect of dietary nutrient density on small intestinal phosphate transport and bone mineralization of broilers during the growing period. Plos one 2016;11:e0153859. https://doi.org/10.1371/journal.pone.0153859
  14. Wang JJ, Wang JR, Fu ZL, Lou P, Ren H. Effects of dietary calcium and phosphorus levels on bone growth in broilers from 1 to 3 weeks of age. Chinese J Anim Nutr 2010;22:1088-95.
  15. Han JC, Yang XD, Zhang T, et al. Effects of 1alpha-hydroxycholecalciferol on growth performance, parameters of tibia and plasma, meat quality, and type IIb sodium phosphate cotransporter gene expression of one- to twenty-one-day-old broilers. Poult Sci 2009;88:323-9. https://doi.org/10.3382/ps.2008-00252
  16. Bradford MM. Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal Biochem 1976;72:248-54. https://doi.org/10.1016/0003-2697(76)90527-3
  17. Li JH, Yuan JM, Guo YM, Sun QJ, Hu XF. The influence of dietary calcium and phosphorus imbalance on intestinal NaPi-IIb and calbindin mRNA expression and tibia parameters of broilers. Asian-Australas. J Anim Sci 2012;25:552-8. https://doi.org/10.5713/ajas.2011.11266
  18. Nahashon SN, Aggrey SE, Adefope NA, Amenyenu A, Wright D. Growth characteristics of pearl gray guinea fowl as predicted by the richards, gompertz, and logistic models. Poult Sci 2006;85: 359-63. https://doi.org/10.1093/ps/85.2.359
  19. Wu ZX. Comparative analysis of different growth model on the early growth stage of Ross 308 broilers. Gansu Sci and Technol 2010; 26:149-52.
  20. Chen ZM. Dynamic growth model and correlative parameters of broilers. [Ph.D. Thesis] Beijing, China: Chinese Academy of Agricultural Sciences; 2004.
  21. Mahmoud KZ, Edens FW. Breeder age affects small intestine development of broiler chicks with immediate or delayed access to feed. Br. Poult Sci 2012;53:32-41. https://doi.org/10.1080/00071668.2011.652596
  22. Takeuchi Y, Kuroda T, Sugimoto T, Shiraki M, Nakamura T. Renal phosphate reabsorption is correlated with the increase in lumbar bone mineral density in patients receiving once-weekly teriparatide. Calcif. Tissue Int 2016;98:186-92. https://doi.org/10.1007/s00223-015-0073-7
  23. Ozeraitiene V, Butenaite V. The evaluation of bone mineral density based on nutritional status, age, and anthropometric parameters in elderly women. Medicina 2006;42:836-42.
  24. Blahos J, Care AD. Alternate-day betamethasone treatment does not affect intestinal absorption of calcium and phosphate and growth rate of chicks. Endocrinol Exp 1981;15:199-204. https://doi.org/10.1111/j.1365-2265.1981.tb00655.x
  25. Fox J, Care AD. Stimulation of duodenal and ileal absorption of phosphate in the chick. Calcif Tissue Res 1978;26:243-5. https://doi.org/10.1007/BF02013265
  26. Yan F, Angel R, Ashwell CM. Characterization of the chicken small intestine type IIb sodium phosphate cotransporter. Poult Sci 2007; 86:67-76. https://doi.org/10.1093/ps/86.1.67
  27. Radanovic T, Wagner CA, Murer H, Biber J. Regulation of intestinal phosphate transport I. Segmental expression and adaptation to low-Pi diet of the type IIb Na+-Pi cotransporter in mouse small intestine. Am J Physiol-Gastr L 2005;288:G496-G500.
  28. Borowitz SM, Granrud GS. Ontogeny of intestinal phosphate absorption in rabbits. Am J Physiol 1992;262:G847-G53.
  29. Wang B, Yin Y. Regulation of the type IIb sodium-dependent phosphate cotransporter expression in the intestine. Front Agr China 2009;3:226-30. https://doi.org/10.1007/s11703-009-0037-7
  30. Zhao B, Nemere I. $1,25(OH)_2D_3$-mediated phosphate uptake in isolated chick intestinal cells: Effect of $24,25(OH)_2D_3$, signal transduction activators, and age. J Cell Biochem 2002;86:497-508. https://doi.org/10.1002/jcb.10246
  31. Nemere I, Farach-Carson MC, Rohe B, et al. Ribozyme knockdown functionally links a $1,25(OH)_2D_3$ membrane binding protein ($1,25D_3$- MARRS) and phosphate uptake in intestinal cells. Proc Natl Acad Sci USA 2004;101:7392-7. https://doi.org/10.1073/pnas.0402207101
  32. Tunsophon S, Nemere I. Protein kinase C isotypes in signal transduction for the $1,25D_3$-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake. Steroids 2010;75:307-13. https://doi.org/10.1016/j.steroids.2010.01.004
  33. Brenza HL, Kimmel-Jehan C, Jehan F, et al. Parathyroid hormone activation of the 25-hydroxyvitamin $D_3-1{\alpha}$-hydroxylase gene promoter. Proc Natl Acad Sci USA 1998;95:1387-91. https://doi.org/10.1073/pnas.95.4.1387
  34. Yu L, Wang YQ, Zhang SY, et al. Gene cloning, sequencing and eukaryotic expression plasmid construction of chicken calbindin- D28k. Chin J Anim Vet Sci 2008;39:1329-35.
  35. Tryfonidou MA, Van den Broek J, Van den Brom WE, Hazewinkel HA. Intestinal calcium absorption in growing dogs is influenced by calcium intake and age but not by growth rate. J Nutr 2002; 132:3363-8. https://doi.org/10.1093/jn/132.11.3363
  36. Adriana VP, Gabriela PAR. Minireview on regulation of intestinal calcium absorption emphasis on molecular mechanisms of transcellular pathway. Int J Gastroenterol 2008;77:22-34. https://doi.org/10.1159/000116623
  37. Richard JW, James CFK. Intestinal calcium absorption in the aged rat: evidence of intestinal resistance to $1,25(OH)_2$ vitamin D. Endocrinology 1998;139:3843-8. https://doi.org/10.1210/endo.139.9.6176
  38. Armbrecht HJ, Boltz MA, Hodam TL. Differences in intestinal calcium and phosphate transport between low and high bone density mice. Gastr L 2002;282:G130-6.
  39. Dobado-Berrios PM, Ferrer M. Age-related changes of plasma alkaline phosphatase and inorganic phosphorus, and late ossification of the cranial roof in the spanish imperial eagle (Aquila adalberti C. L. Brehm, 1861). Physiol Zool 1997;70:421-7. https://doi.org/10.1086/515845
  40. Bergwitz C, Juppner H. Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Annu Rev Med 2010;61:91-104. https://doi.org/10.1146/annurev.med.051308.111339

Cited by

  1. Age, phosphorus, and 25-hydroxycholecalciferol regulate mRNA expression of vitamin D receptor and sodium-phosphate cotransporter in the small intestine of broiler chickens vol.97, pp.4, 2018, https://doi.org/10.3382/ps/pex407
  2. Designing Calcium Phosphate Nanoparticles with the Co-Precipitation Technique to Improve Phosphorous Availability in Broiler Chicks vol.11, pp.10, 2017, https://doi.org/10.3390/ani11102773
  3. Constraints on the modelling of calcium and phosphorus growth of broilers: a systematic review vol.77, pp.4, 2017, https://doi.org/10.1080/00439339.2021.1974804