References
- Coppede F. The potential of epigenetic therapies in neurodegenerative diseases. Front Genet 2014; 5: 220.
- de Lau LM, Breteler MM. Epidemiology of Parkinson's disease. Lancet Neurol 2006; 5: 525-535. https://doi.org/10.1016/S1474-4422(06)70471-9
- Bossy-Wetzel E, Schwarzenbacher R, Lipton SA. Molecular pathways to neurodegeneration. Nat Med 2004; 10: S2-9. https://doi.org/10.1038/nm1067
- Calabrese V, Cornelius C, Mancuso C, Lentile R, Stella AM, Butterfield DA. Redox homeostasis and cellular stress response in aging and neurodegeneration. Methods Mol Biol 2010; 610: 285-308.
- Ghosh N, Ghosh R, Mandal SC. Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease. Free Radic Res 2011; 45: 888-905. https://doi.org/10.3109/10715762.2011.574290
- Wojcik M, Burzynska-Pedziwiatr I, Wozniak LA. A review of natural and synthetic antioxidants important for health and longevity. Curr Med Chem 2010; 17: 3262-3288. https://doi.org/10.2174/092986710792231950
- Guerra-Araiza C, Alvarez-Mejia AL, Sanchez-Torres S, Farfan-Garcia E, Mondragon-Lozano R, Pinto-Almazan R, Salgado-Ceballos H. Effect of natural exogenous antioxidants on aging and on neurodegenerative diseases. Free Radic Res 2013; 47: 451-462. https://doi.org/10.3109/10715762.2013.795649
- Wang CH, Wu SB, Wu YT, Wei YH. Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging. Exp Biol Med (Maywood) 2013; 238: 450-460. https://doi.org/10.1177/1535370213493069
- Wu YT, Wu SB, Lee WY, Wei YH. Mitochondrial respiratory dysfunction-elicited oxidative stress and posttranslational protein modification in mitochondrial diseases. Ann N Y Acad Sci 2010; 1201: 147-156. https://doi.org/10.1111/j.1749-6632.2010.05631.x
- Rego AC, Oliveira CR. Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. Neurochem Res 2003; 28: 1563-1574. https://doi.org/10.1023/A:1025682611389
- Saso L, Firuzi O. Pharmacological applications of antioxidants: lights and shadows. Curr Drug Targets 2014; 15: 1177-1199. https://doi.org/10.2174/1389450115666141024113925
- Ryter SW, Choi AM. Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy. Am J Respir Cell Mol Biol 2009; 41: 251-260. https://doi.org/10.1165/rcmb.2009-0170TR
- Zhang Y and Gordon GB: A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway. Mol Cancer Ther 2004; 3: 885-893.
- Kaspar JW, Niture SK and Jaiswal AK: Nrf2: INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med 2009; 47: 1304-1309. https://doi.org/10.1016/j.freeradbiomed.2009.07.035
- Niture SK, Khatri R and Jaiswal AK: Regulation of Nrf2 - an update. Free Radic Biol Med 2014; 66: 36-44. https://doi.org/10.1016/j.freeradbiomed.2013.02.008
- Surh YJ, Kundu JK, Na HK. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 2008; 74: 1526-1539. https://doi.org/10.1055/s-0028-1088302
- Qaisiya M, Coda Zabetta CD, Bellarosa C, Tiribelli C. Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway. Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway. Cell Signal 2014; 26: 512-520. https://doi.org/10.1016/j.cellsig.2013.11.029
- Ambegaokar SS, Kolson DL. Heme oxygenase-1 dysregulation in the brain: implications for HIV-associated neurocognitive disorders. Curr HIV Res 2014; 12: 174-188. https://doi.org/10.2174/1570162X12666140526122709
- Jazwa A, Cuadrado A. Targeting heme oxygenase- 1 for neuroprotection and neuroinflammation in neurodegenerative diseases. Curr Drug Targets 2010; 11: 1517-1531. https://doi.org/10.2174/1389450111009011517
- Im YK, Choi YH, Hwang WD. Anti-inflammatory effects of CheongNoiMyungShin-Hwan in microglia cells. J Ori Neuropsychiatry 2014; 25: 423-433. https://doi.org/10.7231/jon.2014.25.4.423
- Osman AG, Mekkawy IA, Verreth J, Wuertz S, Kloas W, Kirschbaum F. Monitoring of DNA breakage in embryonic stages of the African catfish Clarias gariepinus (Burchell, 1822) after exposure to lead nitrate using alkaline comet assay. Environ Toxicol 2008; 23: 679-687. https://doi.org/10.1002/tox.20373
- Collins AR. Measuring oxidative damage to DNA and its repair with the comet assay. Biochim Biophys Acta 2014; 1840: 794-800. https://doi.org/10.1016/j.bbagen.2013.04.022
-
Garcia-Canton C, Anadon A, Meredith C.
${\gamma}$ H2AX as a novel endpoint to detect DNA damage: applications for the assessment of the in vitro genotoxicity of cigarette smoke. Toxicol In Vitro 2012; 26: 1075-1086. https://doi.org/10.1016/j.tiv.2012.06.006 - Mates JM, Sanchez-Jimenez FM. Role of reactive oxygen species in apoptosis: implications for cancer therapy. Int J Biochem Cell Biol 2000; 32: 157-170. https://doi.org/10.1016/S1357-2725(99)00088-6
- Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 2000; 29: 222-230. https://doi.org/10.1016/S0891-5849(00)00317-8
- Van Houten B, Woshner V, Santos JH. Role of mitochondrial DNA in toxic responses to oxidative stress. DNA Repair (Amst) 2006; 5: 145-152. https://doi.org/10.1016/j.dnarep.2005.03.002
- Tian X, Guo LP, Hu XL, Huang J, Fan YH, Ren TS, Zhao QC. Protective effects of Arctium lappa L. roots against hydrogen peroxide-induced cell injury and potential mechanisms in SH-SY5Y cells. Cell Mol Neurobiol 2015; 35: 335-344. https://doi.org/10.1007/s10571-014-0129-7
- Pan LL, Liu XH, Jia YL, Wu D, Xiong QH, Gong QH, Wang Y, Zhu YZ. A novel compound derived from danshensu inhibits apoptosis via upregulation of heme oxygenase-1 expression in SH-SY5Y cells. Biochim Biophys Acta 2013; 1830: 2861-2871. https://doi.org/10.1016/j.bbagen.2013.01.008
- Asakura T, Ohkawa K. Chemotherapeutic agents that induce mitochondrial apoptosis. Curr Cancer Drug Targets 2004; 4: 577-590. https://doi.org/10.2174/1568009043332772
- Jourdain A, Martinou JC. Mitochondrial outer- membrane permeabilization and remodelling in apoptosis. Int J Biochem Cell Biol 2009; 41: 1884-1889. https://doi.org/10.1016/j.biocel.2009.05.001
- Duriez PJ, Shah GM. 1997. Cleavage of poly (ADP-ribose) polymerase: a sensitive parameter to study cell death. Biochem Cell Biol 1997; 75: 337-349. https://doi.org/10.1139/o97-043
- Schreiber V, Dantzer F, Ame JC, de Murcia G. Poly (ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol 2006; 7: 517-528. https://doi.org/10.1038/nrm1963
-
Eastman A. Assays for DNA fragmentation, endonucleases, and intracellular pH and
$Ca^{2+}$ associated with apoptosis. Methods Cell Biol 1995; 46: 41-55. -
Kyprianou N, English HF, Isaacs JT. Activation of a
$Ca^{2+}$ -$Mg^{2+}$ -dependent endonuclease as an early event in castration-induced prostatic cell death. Prostate 1998; 13, 103-117. - Paine A, Eiz-Vesper B, Blasczyk R, Immenschuh S. Signaling to heme oxygenase-1 and its anti- inflammatory therapeutic potential. Biochem Pharmacol 2010; 80: 1895-1903. https://doi.org/10.1016/j.bcp.2010.07.014
- McEligot AJ, Yang S, Meyskens FL Jr. Redox regulation by intrinsic species and extrinsic nutrients in normal and cancer cells. Annu Rev Nutr 2005; 25: 261-295. https://doi.org/10.1146/annurev.nutr.25.050304.092633
- Forstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 2008; 5: 338-349. https://doi.org/10.1038/ncpcardio1211
- Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006; 25: 4798-4811. https://doi.org/10.1038/sj.onc.1209608
- Lavrik IN. Systems biology of apoptosis signaling networks. Curr Opin Biotechnol 2010; 21: 551-555. https://doi.org/10.1016/j.copbio.2010.07.001
- Fiandalo MV, Kyprianou N. Caspase control: protagonists of cancer cell apoptosis. Exp Oncol 2012; 34: 165-175.
- Hensley P, Mishra M, Kyprianou N. Targeting caspases in cancer therapeutics. Biol Chem 2013; 394, 831-843.
- Walczak H, Krammer PH. The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems. Exp Cell Res 2000; 256: 58-66. https://doi.org/10.1006/excr.2000.4840
- Schulze-Osthoff K, Ferrari D, Los M, Wesselbrorg S, Peter ME. Apoptosis signaling by death receptors. Eur J Biochem 1998; 254, 439-459. https://doi.org/10.1046/j.1432-1327.1998.2540439.x
- Tenhunen R, Marver HS, Schmid R. The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin. J Lab Clin Med 1970; 75: 410-421.
- Fang J, Seki T, Maeda H. Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev 2009; 61: 290-302. https://doi.org/10.1016/j.addr.2009.02.005
- Dumont A, Hehner SP, Hofmann TG, Ueffing M, Droge W, Schmitz ML. Hydrogen peroxide- induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-kappaB. Oncogene 1999; 18: 747-757. https://doi.org/10.1038/sj.onc.1202325
- Baranano DE, Rao M, Ferris CD, Snyder SH. Biliverdin reductase: a major physiologic cytoprotectant. Proc Natl Acad Sci USA 2002; 99: 16093-16098. https://doi.org/10.1073/pnas.252626999
- Chen J. Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications. Rev Neurosci 2014; 25: 269-280.
- Elbirt KK, Bonkovsky HL. Heme oxygenase: recent advances in understanding its regulation and role. Proc Assoc Am Physicians 1999; 111: 438-447. https://doi.org/10.1111/paa.1999.111.5.438